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dc.creatorPajic, Natasa Bubic
dc.creatorNikolić, Ines
dc.creatorMitsou, Evgenia
dc.creatorPapadimitriou, Vassiliki
dc.creatorXenakis, Aristotelis
dc.creatorRandjelović, Danijela
dc.creatorDobricic, Vladimir
dc.creatorSmitran, Aleksandra
dc.creatorCekic, Nebojsa
dc.creatorCalija, Bojan
dc.creatorSavić, Snežana D.
dc.date.accessioned2021-02-27T21:33:25Z
dc.date.available2020-10-02
dc.date.issued2018
dc.identifier.issn0167-7322
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4291
dc.description.abstractThe aim of this study was development of biocompatible topical microemulsions (MEs) for incorporation and improved dermal delivery of sertaconazole nitrate (SN). For this purpose, phase behavior and microstructure of pseudo-ternary glycereth-7-caprylate/caprate (Emanon EV-E, EV)/cosurfactant/Capryol (TM) 90/water systems were investigated. Furhermore, the influence of these properties on the drug skin delivery was also assessed. Expansion of ME single-phase regions with the use of short chain alcohols was a consequence of the more fluid interface when compared to other investigated systems, which was confirmed by electron paramagnetic resonance spectroscopy-EPR. The chosen bicontinuous to inverted bicontinuous formulations were assessed against the ME based on polysorbate 80 as referent sample. Despite incorporation of SN within the selected formulations induced similar alternations in electrical conductivity, viscosity and pH values, obtained EPR spectra suggested different SN localization: within the oil phase (for most of the EV based formulations), or interacting with the interface (polysorbate 80 based formulation). Due to higher in vitro drug release (12.24%-18.53%), ex vivo SN penetration into porcine ear skin (dermal retention Enhancement Ratio (ERO) ranged from 2.66 to 4.25) and pronounced antifungal activity, the chosen MEs represent promising vehicles for dermal delivery of SN in treatment of cutaneous fungal infections. The biopharmaceutical and skin performance differences obtained with different formulations were possible to be explained on the basis of their physicochemical characteristics.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsembargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Molecular Liquids
dc.subjectGlycereth-7-caprylate/caprateen
dc.subjectSertaconazole nitrateen
dc.subjectMicroemulsionen
dc.subjectElectron paramagnetic resonance spectroscopyen
dc.subjectin vitro releaseen
dc.subjectPenetrationen
dc.titleBiocompatible microemulsions for improved dermal delivery of sertaconazole nitrate: Phase behavior study and microstructure influence on drug biopharamaceutical propertiesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractПајиц, Натаса Бубиц; Николић, Инес; Митсоу, Евгениа; Пападимитриоу, Вассилики; Xенакис, Aристотелис; Ранђеловић, Данијела; Добрициц, Владимир; Смитран, Aлександра; Цекиц, Небојса; Цалија, Бојан; Савић, Снежана Д.;
dc.citation.volume272
dc.citation.spage746
dc.citation.epage758
dc.citation.other272: 746-758
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the article: Pajic, N. B., Nikolić, I., Mitsou, E., Papadimitriou, V., Xenakis, A., Randjelović, D., Dobricic, V., Smitran, A., Cekic, N., Calija, B.,& Savić, S. D. (2018). Biocompatible microemulsions for improved dermal delivery of sertaconazole nitrate: Phase behavior study and microstructure influence on drug biopharamaceutical properties. Journal of Molecular LiquidsElsevier Science Bv, Amsterdam., 272, 746-758. [https://doi.org/10.1016/j.molliq.2018.10.002]
dc.description.otherThe published version: [https://cer.ihtm.bg.ac.rs/handle/123456789/2360]
dc.identifier.doi10.1016/j.molliq.2018.10.002
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs/bitstream/id/19326/bubicpajic2018.pdf
dc.identifier.scopus2-s2.0-85054321735
dc.identifier.wos000451494700083
dc.type.versionacceptedVersion


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