The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.
TY - JOUR
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Vonmoos, F.
AU - Mijin, Dušan
AU - Živković, Predrag M.
AU - Drljević, Katica M.
PY - 2007
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4256
AB - The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.
PB - Elsevier
T2 - Electrochemistry Communications
T1 - The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode
VL - 9
IS - 7
SP - 1643
EP - 1647
DO - 10.1016/j.elecom.2007.03.011
ER -
@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljević, Katica M.",
year = "2007",
abstract = "The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.",
publisher = "Elsevier",
journal = "Electrochemistry Communications",
title = "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode",
volume = "9",
number = "7",
pages = "1643-1647",
doi = "10.1016/j.elecom.2007.03.011"
}
Avramov Ivić, M., Petrović, S. D., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljević, K. M.. (2007). The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications
Elsevier., 9(7), 1643-1647.
https://doi.org/10.1016/j.elecom.2007.03.011
Avramov Ivić M, Petrović SD, Vonmoos F, Mijin D, Živković PM, Drljević KM. The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications. 2007;9(7):1643-1647.
doi:10.1016/j.elecom.2007.03.011 .
Avramov Ivić, Milka, Petrović, Slobodan D., Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljević, Katica M., "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode" in Electrochemistry Communications, 9, no. 7 (2007):1643-1647,
https://doi.org/10.1016/j.elecom.2007.03.011 . .
