The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode
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2007
Authors
Avramov Ivić, Milka
Petrović, Slobodan D.
Vonmoos, F.
Mijin, Dušan

Živković, Predrag M.

Drljević, Katica M.
Article (Published version)

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The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.
Keywords:
Clarithromycin / Cyclic voltammetry / FTIR spectroscopy / Gold electrode / Qualitative determinationSource:
Electrochemistry Communications, 2007, 9, 7, 1643-1647Publisher:
- Elsevier
Funding / projects:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-142063)
DOI: 10.1016/j.elecom.2007.03.011
ISSN: 1388-2481
WoS: 000248089400042
Scopus: 2-s2.0-34250369288
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IHTMTY - JOUR AU - Avramov Ivić, Milka AU - Petrović, Slobodan D. AU - Vonmoos, F. AU - Mijin, Dušan AU - Živković, Predrag M. AU - Drljević, Katica M. PY - 2007 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4256 AB - The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. PB - Elsevier T2 - Electrochemistry Communications T1 - The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode VL - 9 IS - 7 SP - 1643 EP - 1647 DO - 10.1016/j.elecom.2007.03.011 ER -
@article{ author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljević, Katica M.", year = "2007", abstract = "The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.", publisher = "Elsevier", journal = "Electrochemistry Communications", title = "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode", volume = "9", number = "7", pages = "1643-1647", doi = "10.1016/j.elecom.2007.03.011" }
Avramov Ivić, M., Petrović, S. D., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljević, K. M.. (2007). The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications Elsevier., 9(7), 1643-1647. https://doi.org/10.1016/j.elecom.2007.03.011
Avramov Ivić M, Petrović SD, Vonmoos F, Mijin D, Živković PM, Drljević KM. The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications. 2007;9(7):1643-1647. doi:10.1016/j.elecom.2007.03.011 .
Avramov Ivić, Milka, Petrović, Slobodan D., Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljević, Katica M., "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode" in Electrochemistry Communications, 9, no. 7 (2007):1643-1647, https://doi.org/10.1016/j.elecom.2007.03.011 . .