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dc.creatorKaluđerović, Goran N.
dc.creatorSchmidt, Harry
dc.creatorPaschke, Reinhard
dc.creatorKalinowski, Bernd
dc.creatorDietrich, Andrea
dc.creatorMueller, Thomas
dc.creatorSteinborn, Dirk
dc.date.accessioned2021-02-24T09:27:41Z
dc.date.available2021-02-24T09:27:41Z
dc.date.issued2007
dc.identifier.issn0162-0134
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4252
dc.description.abstractFour dipeptide complexes of the type [PtX2(dipeptide)] · H2O (X = Cl, I, dipeptide = l-methionylglycine, l-methionyl-l-leucine) were prepared. The complexes were characterized by 1H, 13C, 195Pt NMR and infrared spectroscopy, DTG and elemental analysis. From the infrared, 1H and 13C NMR spectroscopy it was concluded that dipeptides coordinate bidentately via sulfur and amine nitrogen donor atoms. Confirmed with 13C and 195Pt NMR spectroscopy, each of the complexes exists in two diastereoisomeric forms, which are related by inversion of configuration at the sulfur atom. The 1H NMR spectrum for the platinum(II) complex with l-methionylglycine and chloro ligands exhibited reversible, intramolecular inversion of configuration at the S atom; ΔG≠ = 72 kJ mol−1 at coalescence temperature 349 K was calculated. In vitro cytotoxicity studies using the human tumor cell lines liposarcoma, lung carcinoma A549 and melanoma 518A2 revealed considerable activity of the platinum(II) complex with l-methionylglycine and chloro ligands. Further in vitro cytotoxic evaluation using human testicular germ cell tumor cell lines 1411HP and H12.1 and colon carcinoma cell line DLD-1 showed moderate cytotoxic activity for all platinum(II) complexes only in the cisplatin-sensitive cell line H12.1. Platinum uptake studies using atomic absorption spectroscopy indicated no relationship between uptake and activity. Potential antitumoral activity of this class of platinum(II) complexes is dependent on the kind of ligands as well as on tumor cell type.sr
dc.language.isoensr
dc.publisherElseviersr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Inorganic Biochemistrysr
dc.subjectAntiproliferative activitysr
dc.subjectDipeptidesr
dc.subjectPlatinum uptakesr
dc.subjectPlatinum(II) complexessr
dc.titlePlatinum(II) complexes with l-methionylglycine and l-methionyl-l-leucine ligands: Synthesis, characterization and in vitro antitumoral activitysr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractСтеинборн, Дирк; Диетрицх, Aндреа; Пасцхке, Реинхард; Сцхмидт, Харрy; Калуђеровић, Горан Н.; Муеллер, Тхомас; Калиноwски, Бернд;
dc.citation.volume101
dc.citation.issue3
dc.citation.spage543
dc.citation.epage549
dc.citation.rankM21
dc.identifier.pmid17223197
dc.identifier.doi10.1016/j.jinorgbio.2006.11.016
dc.identifier.scopus2-s2.0-33846682210
dc.identifier.wos000244773800018
dc.type.versionpublishedVersionsr


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