Приказ основних података о документу
Efflux of cholesterol and phospholipids derived from the haemoglobin-lipid adduct in human red blood cells into plasma
dc.creator | Nikolić, Milan R. | |
dc.creator | Stanić-Vučinić, Dragana | |
dc.creator | Baričević, Ivona I. | |
dc.creator | Jones, David R.B. | |
dc.creator | Nedić, Olgica | |
dc.creator | Niketić, Vesna | |
dc.date.accessioned | 2021-02-22T21:49:16Z | |
dc.date.available | 2021-02-22T21:49:16Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4247 | |
dc.description.abstract | Objective: The interior of red blood cells (RBCs) contains a variable amount of cholesterol and phospholipids bound to haemoglobin (Hb). This current study was devised to determine if this pool of lipids (termed Hb-Ch) was available for exchange with plasma lipoproteins. Design and methods: We studied the in vitro efflux of lipids from human RBCs into fasting plasma in men with either low (control group) or high Hb-Ch (study group). Results: When plasma was incubated with a two-fold excess of autologous RBCs the plasma cholesterol level increased due to a decrease in the level of cholesterol from the RBC membrane (in the control group) and due to a decrease in the level of cholesterol both from the RBC membrane and the Hb-Ch fraction (in the study group). The loss of Hb-Ch-derived phospholipids during lipid efflux was roughly equal to that of Hb-Ch-derived cholesterol. The loss of RBC cholesterol into plasma high-density lipoproteins (HDL) was more pronounced in our study group and correlated with the loss of cholesterol from Hb-Ch. Conclusion: The Hb-Ch adduct significantly contributes to the lipid efflux from RBCs into plasma. The majority of cholesterol released from Hb-Ch appears in the plasma HDL fraction suggesting that Hb-Ch may play a role in reverse cholesterol transport in vivo. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142017/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Clinical Biochemistry | sr |
dc.subject | Cholesterol | sr |
dc.subject | HDL cholesterol | sr |
dc.subject | Haemoglobin | sr |
dc.subject | Lipoproteins | sr |
dc.subject | Phospholipids | sr |
dc.subject | Red blood cells | sr |
dc.title | Efflux of cholesterol and phospholipids derived from the haemoglobin-lipid adduct in human red blood cells into plasma | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Никетић, Весна; Николић, Милан Р.; Станић-Вучинић, Драгана; Баричевић, Ивона И.; Јонес, Давид Р.Б.; Недић, Олгица; | |
dc.citation.volume | 40 | |
dc.citation.issue | 5-6 | |
dc.citation.spage | 305 | |
dc.citation.epage | 309 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 17291471 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2006.11.005 | |
dc.identifier.scopus | 2-s2.0-33847313315 | |
dc.identifier.wos | 000244997400004 | |
dc.type.version | publishedVersion | sr |