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dc.creatorGledović, Ana
dc.creatorJanošević Ležaić, Aleksandra
dc.creatorNikolić, Ines
dc.creatorTasić-Kostov, Marija Z.
dc.creatorAntić-Stanković, Jelena
dc.creatorKrstonošić, Veljko S.
dc.creatorRanđelović, Danijela
dc.creatorBožić, Dragana
dc.creatorIlić, Dušan
dc.creatorTamburić, Slobodanka D.
dc.creatorSavić, Snežana
dc.date.accessioned2021-02-18T11:49:36Z
dc.date.available2021-02-18T11:49:36Z
dc.date.issued2021
dc.identifier.issn2079-4991
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4243
dc.description.abstractThis study focuses on the development of biocompatible oil-in-water (O/W) nanoemulsions based on polyglycerol esters, as promising carriers for natural actives: red raspberry seed oil—RO and hydro-glycolic fruit extracts from red raspberry—RE and French oak—FE. Nanoemulsions were obtained via phase inversion composition (PIC) method at room temperature by dilution of microemulsion phase, confirmed by visual appearance, percentage of transmittance, microscopic, rheological and differential scanning calorimetry (DSC) investigations. The results have shown that the basic RO-loaded formulation could be further enriched with hydro-glycolic fruit extracts from red raspberry or French oak, while keeping a semi-transparent appearance due to the fine droplet size (Z-ave: 50 to 70 nm, PDI value _ 0.1). The highest antioxidant activity (~92% inhibition of the DPPH radical) was achieved in the formulation containing both lipophilic (RO) and hydrophilic antioxidants (FE), due to their synergistic effect. The nanoemulsion carrier significantly increased the selective cytotoxic effect of RO towards malignant melanoma (Fem-X) cells, compared to normal human keratinocytes (HaCaT). In vivo study on human volunteers showed satisfactory safety profiles and significant improvement in skin hydration during 2 h after application for all nanoemulsions. Therefore, polyglycerol ester-based nanoemulsions can be promoted as effective carriers for red raspberry seed oil and/or hydro-glycolic fruit extracts in topical formulations intended for skin protection and hydration.sr
dc.language.isoensr
dc.publisherMDPI AGsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//sr
dc.rightsopenAccesssr
dc.sourceNanomaterialssr
dc.subjectnanoemulsionsr
dc.subjectphase inversion composition (PIC)sr
dc.subjectbiocompatiblesr
dc.subjectlow energysr
dc.subjectpolyglycerol estersr
dc.subjectred raspberry seed oilsr
dc.subjectFrench oak fruit extractsr
dc.subjectantioxidant activitysr
dc.subjectMTTsr
dc.subjectskin hydrationsr
dc.titlePolyglycerol Ester-Based Low Energy Nanoemulsions with Red Raspberry Seed Oil and Fruit Extracts: Formulation Development toward Effective In Vitro/In Vivo Bioperformancesr
dc.typearticlesr
dc.rights.licenseBYsr
dcterms.abstractКрстоношић, Вељко С.; Николић, Инес; Aнтић-Станковић, Јелена; Ранђеловић, Данијела; Божић, Драгана; Илић, Душан; Тамбурић, Слободанка Д.; Савић, Снежана; Јаношевић Лежаић, Aлександра; Тасић-Костов, Марија З.; Гледовић, Aна;
dc.citation.volume11
dc.citation.issue1
dc.citation.spage1
dc.citation.epage21
dc.citation.rankM21~
dc.identifier.pmid33467701
dc.identifier.doi10.3390/nano11010217
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/19177/nanomaterials-11-00217-v3.pdf
dc.identifier.scopus2-s2.0-85100166444
dc.identifier.wos000610664200001
dc.type.versionpublishedVersionsr


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