The Role of Proteomics in Personalized Medicine
Само за регистроване кориснике
2016
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The consequences of the differences in the genome of each human individual are the variation in expressed protein isoforms, as well as the changes of the level and timing of protein expression and of the spatial distribution of expressed proteins. These differences are defined as differences in human proteome. The consequence of the changes of individual proteome is the difference in protein–protein interactions (interactome). The network of interactions between proteins underlines every single process in a living organism and makes it happen. This complex network is kept in more or less optimal homeostasis that is unique for each organism. Thus, the capacity of the interactome to overcome disease condition differs among individuals, e.g., to compensate over or down regulations of different processes that are induced, e.g., by mutations. Recent technological advances in high throughput proteomic techniques enabled fast and deep analysis of human proteome and also some understanding of ...the complex mechanism of protein–protein interactions. However, the human proteome analysis is still not complete, and further improvements in both analytical techniques and accompanying bioinformatics tools are necessary. In this chapter, current state of application of different proteomic approaches for personalized patient proteome profiling and search for diagnostic and prognostic disease biomarkers are presented and the contribution of proteome analysis to personalized approach in most frequent diseases in developed Western World, namely cancer, cardiovascular, urological and neurodegenerative diseases, diabetes mellitus and allergies, has been reviewed.
Кључне речи:
Epidermal Growth Factor Receptor / Personalized Medicine / Protein Interaction Network / Image Mass Spectrometry / Aristolochic AcidИзвор:
Personalized medicine: A New Medical and Social Challenge, 2016, 2, 179-218Издавач:
- Springer
Институција/група
IHTMTY - CHAP AU - Josić, Đuro AU - Anđelković, Uroš PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4232 AB - The consequences of the differences in the genome of each human individual are the variation in expressed protein isoforms, as well as the changes of the level and timing of protein expression and of the spatial distribution of expressed proteins. These differences are defined as differences in human proteome. The consequence of the changes of individual proteome is the difference in protein–protein interactions (interactome). The network of interactions between proteins underlines every single process in a living organism and makes it happen. This complex network is kept in more or less optimal homeostasis that is unique for each organism. Thus, the capacity of the interactome to overcome disease condition differs among individuals, e.g., to compensate over or down regulations of different processes that are induced, e.g., by mutations. Recent technological advances in high throughput proteomic techniques enabled fast and deep analysis of human proteome and also some understanding of the complex mechanism of protein–protein interactions. However, the human proteome analysis is still not complete, and further improvements in both analytical techniques and accompanying bioinformatics tools are necessary. In this chapter, current state of application of different proteomic approaches for personalized patient proteome profiling and search for diagnostic and prognostic disease biomarkers are presented and the contribution of proteome analysis to personalized approach in most frequent diseases in developed Western World, namely cancer, cardiovascular, urological and neurodegenerative diseases, diabetes mellitus and allergies, has been reviewed. PB - Springer T2 - Personalized medicine: A New Medical and Social Challenge T1 - The Role of Proteomics in Personalized Medicine VL - 2 SP - 179 EP - 218 DO - 10.1007/978-3-319-39349-0_9 ER -
@inbook{ author = "Josić, Đuro and Anđelković, Uroš", year = "2016", abstract = "The consequences of the differences in the genome of each human individual are the variation in expressed protein isoforms, as well as the changes of the level and timing of protein expression and of the spatial distribution of expressed proteins. These differences are defined as differences in human proteome. The consequence of the changes of individual proteome is the difference in protein–protein interactions (interactome). The network of interactions between proteins underlines every single process in a living organism and makes it happen. This complex network is kept in more or less optimal homeostasis that is unique for each organism. Thus, the capacity of the interactome to overcome disease condition differs among individuals, e.g., to compensate over or down regulations of different processes that are induced, e.g., by mutations. Recent technological advances in high throughput proteomic techniques enabled fast and deep analysis of human proteome and also some understanding of the complex mechanism of protein–protein interactions. However, the human proteome analysis is still not complete, and further improvements in both analytical techniques and accompanying bioinformatics tools are necessary. In this chapter, current state of application of different proteomic approaches for personalized patient proteome profiling and search for diagnostic and prognostic disease biomarkers are presented and the contribution of proteome analysis to personalized approach in most frequent diseases in developed Western World, namely cancer, cardiovascular, urological and neurodegenerative diseases, diabetes mellitus and allergies, has been reviewed.", publisher = "Springer", journal = "Personalized medicine: A New Medical and Social Challenge", booktitle = "The Role of Proteomics in Personalized Medicine", volume = "2", pages = "179-218", doi = "10.1007/978-3-319-39349-0_9" }
Josić, Đ.,& Anđelković, U.. (2016). The Role of Proteomics in Personalized Medicine. in Personalized medicine: A New Medical and Social Challenge Springer., 2, 179-218. https://doi.org/10.1007/978-3-319-39349-0_9
Josić Đ, Anđelković U. The Role of Proteomics in Personalized Medicine. in Personalized medicine: A New Medical and Social Challenge. 2016;2:179-218. doi:10.1007/978-3-319-39349-0_9 .
Josić, Đuro, Anđelković, Uroš, "The Role of Proteomics in Personalized Medicine" in Personalized medicine: A New Medical and Social Challenge, 2 (2016):179-218, https://doi.org/10.1007/978-3-319-39349-0_9 . .