This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of ...floating drug delivery system using an environmental friendly process.
TY - JOUR
AU - Milovanović, Stoja
AU - Đuriš, Jelena
AU - Dapčević, Aleksandra
AU - Lučić-Škorić, Marija
AU - Medarević, Đorđe
AU - Pavlović, Stefan
AU - Ibrić, Svetlana
PY - 2021
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4198
AB - This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
PB - Springer
T2 - Journal of Polymer Research
T1 - Preparation of floating polymer-valsartan delivery systems using supercritical CO2
VL - 28
SP - 74
DO - 10.1007/s10965-021-02440-1
ER -
@article{
author = "Milovanović, Stoja and Đuriš, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarević, Đorđe and Pavlović, Stefan and Ibrić, Svetlana",
year = "2021",
url = "https://cer.ihtm.bg.ac.rs/handle/123456789/4198",
abstract = "This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.",
publisher = "Springer",
journal = "Journal of Polymer Research",
title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2",
volume = "28",
pages = "74",
doi = "10.1007/s10965-021-02440-1"
}
Milovanović S, Đuriš J, Dapčević A, Lučić-Škorić M, Medarević Đ, Pavlović S, Ibrić S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. Journal of Polymer Research. 2021;28:74
Milovanović, S., Đuriš, J., Dapčević, A., Lučić-Škorić, M., Medarević, Đ., Pavlović, S.,& Ibrić, S. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2.
Journal of Polymer ResearchSpringer., 28, 74.
https://doi.org/10.1007/s10965-021-02440-1
Milovanović Stoja, Đuriš Jelena, Dapčević Aleksandra, Lučić-Škorić Marija, Medarević Đorđe, Pavlović Stefan, Ibrić Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" 28 (2021):74,
https://doi.org/10.1007/s10965-021-02440-1 .
,