The Reductive Conversion of Some Cyclic and Acyclic vic-Epoxides to Alcohols by Means of Lithium Aluminium Hydride/Aluminium Trichloride
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Unsubstituted medium‐ring 1,2‐epoxycycloalkanes and certain vic‐epoxyalkanes are reduced to the corresponding alcohols very slowly when LiAlH4 alone is used as reducing agent. However, the combination of LiAlH4 and AlCl3, in a 2:1 molar ratio (with respect to 1 mol‐equiv. of epoxide) used in refluxing Et2O, greatly enhances these reductions, rendering them of interest for practical purposes.
Keywords:1,2‐epoxycycloalkanes / Reduction / alcohols / LiAlH4 / AlCl3
Source:Helvetica Chimica Acta, 1985, 68, 7, 2030-2032