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dc.creatorBjelaković, Mira
dc.creatorGođevac, Dejan
dc.creatorMilić, Dragana
dc.date.accessioned2021-02-02T06:30:47Z
dc.date.available2021-02-02T06:30:47Z
dc.date.issued2007
dc.identifier.issn0008-6223
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4183
dc.description.abstractFour new fullero-steroids were synthesized starting from gamma-aminobutyric acid (GABA)-incorporated fulleropyrrolidine and corresponding sterols. The synthesis, characterization, preliminary study on in vitro antioxidant activity as well as the steady state photophysical properties are presented. All synthesized compounds showed antioxidant activity 2-3-fold higher than the parent fullerene. The most active compound appeared to be as potent as standard antioxidant BHT (2,6-di-tert-butyl-4-methylphenol). Also, all of them fluoresce 6-8-fold stronger than C-60, thus representing potential irradiation assisted pro-oxidants. With significantly increased lipophilicity, it could be expected that attached steroidal subunit enables better penetration Of C60 to living cell membranes, thus facilitating its antioxidant activity. Based on all obtained results, newly synthesized covalent fullero-steroidal conjugates represent good candidates for potential antioxidants as well as pro-oxidants. (c) 2007 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142049/RS//
dc.rightsrestrictedAccess
dc.sourceCarbon
dc.subjectsteroids
dc.subjectfullerenes
dc.subjectfullero-steroids
dc.subjectsynthesis
dc.subjectcharacterization
dc.subjectantioxidant activity
dc.titleSynthesis and antioxidant properties of fullero-steroidal covalent conjugatesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилић, Драгана; Бјелаковић, Мира; Гођевац, Дејан;
dc.citation.volume45
dc.citation.issue11
dc.citation.spage2260
dc.citation.epage2265
dc.citation.other45(11): 2260-2265
dc.citation.rankaM21
dc.identifier.doi10.1016/j.carbon.2007.06.027
dc.identifier.rcubKon_1836
dc.identifier.scopus2-s2.0-34548500386
dc.identifier.wos000250185900019
dc.type.versionpublishedVersionen


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