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dc.creatorNikolić, Milan
dc.creatorStanić, Dragana
dc.creatorAntonijevic, Nadežda
dc.creatorNiketić, Vesna
dc.date.accessioned2021-01-28T15:47:29Z
dc.date.available2021-01-28T15:47:29Z
dc.date.issued2004
dc.identifier.issn0009-9120
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4167
dc.description.abstractObjective: To study lipid fraction that is occasionally observed in red blood cell (RBC) hemolysate (supernatants from which membranes were separated). Study design: Plasma lipid profiles, cholesterol (Ch) and phospholipids (PL) in intact RBCs, RBC membranes and hemolysates were examined in young healthy male population in winter and summer. Results: The RBC Ch and PL content was significantly higher than in membranes, both in winter and summer. The "excess" of cholesterol (associated with phospholipid) was bound to hemoglobin yielding Hb-lipid adduct (Hb-Ch), the pools in the RBC membrane remaining virtually unaltered. Levels of hemoglobin- lipid complex (Hb-Ch), which were significantly higher in winter than in summer (30% and 19% of the total Hb, respectively), positively correlated with plasma HDL cholesterol levels. Conclusion: To our knowledge, this is the first demonstration of cholesterol binding to Hb. The results suggest influence of plasma lipoprotein metabolism on the formation of Hb-Ch. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.en
dc.publisherElsevier
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectcholesterolen
dc.subjectHDL cholesterolen
dc.subjecthemoglobinen
dc.subjectred blood cellsen
dc.subjecthemoglobin-lipiden
dc.subjectseasonal variationen
dc.titleCholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНикетиц, Весна; Aнтонијевиц, Надежда; Станић, Драгана; Николић, Милан;
dc.citation.volume37
dc.citation.issue1
dc.citation.spage22
dc.citation.epage26
dc.citation.other37(1): 22-26
dc.citation.rankM22
dc.identifier.pmid14675558
dc.identifier.doi10.1016/j.clinbiochem.2003
dc.identifier.rcubKon_1560
dc.identifier.scopus2-s2.0-0348111560
dc.identifier.wos000187580700004
dc.type.versionpublishedVersionen


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