CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation?

Authorized Users Only
2004
Authors
Nikolić, Milan
Stanić, Dragana
Antonijevic, Nadežda
Niketić, Vesna
Article (Published version)
Metadata
Show full item record
Abstract
Objective: To study lipid fraction that is occasionally observed in red blood cell (RBC) hemolysate (supernatants from which membranes were separated). Study design: Plasma lipid profiles, cholesterol (Ch) and phospholipids (PL) in intact RBCs, RBC membranes and hemolysates were examined in young healthy male population in winter and summer. Results: The RBC Ch and PL content was significantly higher than in membranes, both in winter and summer. The "excess" of cholesterol (associated with phospholipid) was bound to hemoglobin yielding Hb-lipid adduct (Hb-Ch), the pools in the RBC membrane remaining virtually unaltered. Levels of hemoglobin- lipid complex (Hb-Ch), which were significantly higher in winter than in summer (30% and 19% of the total Hb, respectively), positively correlated with plasma HDL cholesterol levels. Conclusion: To our knowledge, this is the first demonstration of cholesterol binding to Hb. The results suggest influence of plasma lipoprotein metabolism on the forma...tion of Hb-Ch. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.

Keywords:
cholesterol / HDL cholesterol / hemoglobin / red blood cells / hemoglobin-lipid / seasonal variation
Source:
Clinical Biochemistry, 2004, 37, 1, 22-26
Publisher:
  • Elsevier

DOI: 10.1016/j.clinbiochem.2003

ISSN: 0009-9120

PubMed: 14675558

WoS: 000187580700004

Scopus: 2-s2.0-0348111560
[ Google Scholar ]
15
17
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/4167
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB