dc.creator | Gomez-Ruiz, Santiago | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Prashar, Sanjiv | |
dc.creator | Polo-Ceron, Dorian | |
dc.creator | Fajardo, Mariano | |
dc.creator | Žižak, Željko | |
dc.creator | Sabo, Tibor | |
dc.creator | Juranić, Zorica | |
dc.date.accessioned | 2021-01-21T13:47:20Z | |
dc.date.available | 2021-01-21T13:47:20Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.issn | 1873-3344 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4130 | |
dc.description.abstract | A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods.
The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human
myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear
cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds
[Ti{Me2Si(g5-C5Me4)(g5-C5H3{CMe2CH2CH2CH@CH2})}Cl2] (8), [Ti{Me(CH2@CH)Si(g5-C5Me4)(g5-C5H4)}Cl2] (9) and [Ti(g5-
C5H4{CMe2CH2CH2CH@CH2})2Cl2] (12) showed higher cytotoxic activities (IC50 values from 24 } 3 to 151 } 10 lM) relative to complexes
bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2@CH)Me2SiCH2CH2}Si(g5-
C5Me4)(g5-C5H4)}Cl2] (10) and [Ti{Me{(CH2@CH)3SiCH2CH2}Si(g5-C5Me4)(g5-C5H4)}Cl2] (11) which causes a dramatic decrease
of the cytotoxicity (IC50 values from 155 } 9 to >200 lM). In addition, the synthesis of the analogous niobocene complex [Nb(g5-
C5H4{CMe2CH2CH2CH=CH2})2Cl2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8,
9 and 12 and the X-ray crystal structure of 13 are reported. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | Ministerio de Educacio´n y Ciencia, Spain (Grant no. CTQ2005-07918-C02-02/BQU), | sr |
dc.relation | Comunidad de Madrid (S-0505/PPQ-0328) | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Inorganic Biochemistry | sr |
dc.subject | Anticancer drugs | sr |
dc.subject | Titanocene | sr |
dc.subject | Adenocarcinoma HeLa | sr |
dc.subject | Human myelogenous leukemia K562 | sr |
dc.subject | Human malignant melanoma Fem-x | sr |
dc.title | Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Жижак, Жељко; Јуранић, Зорица; Прасхар, Сањив; Гомез-Руиз, Сантиаго; Сабо, Тибор; Фајардо, Мариано; Поло-Церон, Дориан; Калуђеровић, Горан; | |
dc.citation.volume | 102 | |
dc.citation.issue | 8 | |
dc.citation.spage | 1558 | |
dc.citation.epage | 1570 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 18353439 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2008.02.001 | |
dc.identifier.scopus | 2-s2.0-47049100123 | |
dc.identifier.wos | 000258012000002 | |
dc.type.version | publishedVersion | sr |