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dc.creatorGomez-Ruiz, Santiago
dc.creatorKaluđerović, Goran N.
dc.creatorPrashar, Sanjiv
dc.creatorPolo-Ceron, Dorian
dc.creatorFajardo, Mariano
dc.creatorŽižak, Željko
dc.creatorSabo, Tibor
dc.creatorJuranić, Zorica
dc.date.accessioned2021-01-21T13:47:20Z
dc.date.available2021-01-21T13:47:20Z
dc.date.issued2008
dc.identifier.issn0162-0134
dc.identifier.issn1873-3344
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4130
dc.description.abstractA variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(g5-C5Me4)(g5-C5H3{CMe2CH2CH2CH@CH2})}Cl2] (8), [Ti{Me(CH2@CH)Si(g5-C5Me4)(g5-C5H4)}Cl2] (9) and [Ti(g5- C5H4{CMe2CH2CH2CH@CH2})2Cl2] (12) showed higher cytotoxic activities (IC50 values from 24 } 3 to 151 } 10 lM) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2@CH)Me2SiCH2CH2}Si(g5- C5Me4)(g5-C5H4)}Cl2] (10) and [Ti{Me{(CH2@CH)3SiCH2CH2}Si(g5-C5Me4)(g5-C5H4)}Cl2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 } 9 to >200 lM). In addition, the synthesis of the analogous niobocene complex [Nb(g5- C5H4{CMe2CH2CH2CH=CH2})2Cl2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationMinisterio de Educacio´n y Ciencia, Spain (Grant no. CTQ2005-07918-C02-02/BQU),sr
dc.relationComunidad de Madrid (S-0505/PPQ-0328)sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Inorganic Biochemistrysr
dc.subjectAnticancer drugssr
dc.subjectTitanocenesr
dc.subjectAdenocarcinoma HeLasr
dc.subjectHuman myelogenous leukemia K562sr
dc.subjectHuman malignant melanoma Fem-xsr
dc.titleCytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugssr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractЖижак, Жељко; Јуранић, Зорица; Прасхар, Сањив; Гомез-Руиз, Сантиаго; Сабо, Тибор; Фајардо, Мариано; Поло-Церон, Дориан; Калуђеровић, Горан;
dc.citation.volume102
dc.citation.issue8
dc.citation.spage1558
dc.citation.epage1570
dc.citation.rankM21
dc.identifier.pmid18353439
dc.identifier.doi10.1016/j.jinorgbio.2008.02.001
dc.identifier.scopus2-s2.0-47049100123
dc.identifier.wos10.1016/j.jinorgbio.2008.02.001
dc.type.versionpublishedVersionsr


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