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Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes
dc.creator | Gómez-Ruiz, Santiago | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Prashar, Sanjiv | |
dc.creator | Hey-Hawkins, Evamarie | |
dc.creator | Erić, Aleksandra | |
dc.creator | Žižak, Željko | |
dc.creator | Juranić, Zorica | |
dc.date.accessioned | 2021-01-21T13:28:56Z | |
dc.date.available | 2021-01-21T13:28:56Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4125 | |
dc.description.abstract | The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5- dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV) chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds [SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5), [SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex [{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5- dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH) and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3) with IC50 value of 0.15 } 0.01, 0.051 } 0.004, 0.074 } 0.004, 0.20 } 0.01, 0.15 } 0.02 on HeLa, K562, Femx, rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin in all the tested cells and relative high selectivity especially on K562 cells. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | Ministerio de Educación y Ciencia, Spain (Grant No. CTQ2005-07918-C02- 02/BQU) | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Inorganic Biochemistry | sr |
dc.subject | Anticancer drugs | sr |
dc.subject | Tin | sr |
dc.subject | Adenocarcinoma HeLa | sr |
dc.subject | Human myelogenous leukemia K562 | sr |
dc.subject | Human malignant melanoma Fem-x | sr |
dc.title | Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Хеy-Хаwкинс, Евамарие; Калуђеровић, Горан Н.; Прасхар, Сањив; Жижак, Жељко; Гóмез-Руиз, Сантиаго; Јуранић, Зорица; Ериц, Aлександра; | |
dc.citation.volume | 102 | |
dc.citation.issue | 12 | |
dc.citation.spage | 2087 | |
dc.citation.epage | 2096 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 18760840 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2008.07.009 | |
dc.identifier.scopus | 2-s2.0-55549104361 | |
dc.identifier.wos | 000261429700009 | |
dc.type.version | publishedVersion | sr |