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Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes

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2008
Authors
Gómez-Ruiz, Santiago
Kaluđerović, Goran N.
Prashar, Sanjiv
Hey-Hawkins, Evamarie
Erić, Aleksandra
Žižak, Željko
Juranić, Zorica
Article (Published version)
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Abstract
The reaction of 3-methoxyphenylacetic acid (3-MPAH), 4-methoxyphenylacetic acid (4-MPAH), 2,5- dimethyl-3-furoic acid (DMFUH) or 1,4-benzodioxane-6-carboxylic acid (BZDOH) with triphenyltin(IV) chloride (1:1) or diphenyltin(IV) dichloride (2:1) in the presence of triethylamine yielded the compounds [SnPh3(3-MPA)] (1), [SnPh3(4-MPA)] (2), [SnPh3(DMFU)] (3), [SnPh3(BZDO)] (4), [SnPh2(3-MPA)2] (5), [SnPh2(4-MPA)2] (6), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8), respectively. The tetranuclear complex [{Me2(DMFU)SnOSn(DMFU)Me2}2] (9) was prepared by the reaction of dimethyltin(IV) oxide and 2,5- dimethyl-3-furoic acid (DMFUH). The molecular structures of 3, 4 and 9, were determined by X-ray diffraction studies. The cytotoxic activity of the carboxylic acids (3-MPAH, 4-MPAH, BZDOH and DMFUH) and di (5–8) and triphenyltin(IV) complexes (2–4) was tested against tumor cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immun...ocompetent cells, peripheral blood mononuclear cells PBMC. Triphenyltin(IV) complexes show higher activities than the diphenyltin(IV) derivatives. The most active compound is [SnPh3(DMFU)] (3) with IC50 value of 0.15 } 0.01, 0.051 } 0.004, 0.074 } 0.004, 0.20 } 0.01, 0.15 } 0.02 on HeLa, K562, Femx, rested and stimulated PBMC, respectively, while the most selective are [SnPh2(3-MPA)2] (5), [SnPh2(DMFU)2] (7) and [SnPh2(BZDO)2] (8). Compounds 3, 5, 7 and 8 present higher activities than cisplatin in all the tested cells and relative high selectivity especially on K562 cells.

Keywords:
Anticancer drugs / Tin / Adenocarcinoma HeLa / Human myelogenous leukemia K562 / Human malignant melanoma Fem-x
Source:
Journal of Inorganic Biochemistry, 2008, 102, 12, 2087-2096
Publisher:
  • Elsevier
Projects:
  • Ministerio de Educación y Ciencia, Spain (Grant No. CTQ2005-07918-C02- 02/BQU)
  • Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)
  • Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)

DOI: 10.1016/j.jinorgbio.2008.07.009

ISSN: 0162-0134

PubMed: 18760840

WoS: 000261429700009

Scopus: 2-s2.0-55549104361
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URI
https://cer.ihtm.bg.ac.rs/handle/123456789/4125
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