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dc.creatorIsaković, Aleksandra
dc.creatorMarković, Zoran M.
dc.creatorNikolić, Nadežda
dc.creatorTodorović-Marković, Biljana
dc.creatorVranješ-Đurić, Sanja
dc.creatorHarhaji, Ljubica
dc.creatorRaičević, Nevena
dc.creatorRomčević, Nebojša
dc.creatorVasiljević-Radović, Dana
dc.creatorDramićanin, Miroslav
dc.creatorTrajković, Vladimir
dc.date.accessioned2021-01-21T12:46:43Z
dc.date.available2021-01-21T12:46:43Z
dc.date.issued2006
dc.identifier.issn0142-9612
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4120
dc.description.abstractWe investigated the effect of γ-irradiation on the cytotoxicity of pure C 60 solubilized in water by using tetrahydrofuran (THF/n-C 60 or THF/n-C 60 ). In contrast to THF/n-C 60 , its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C 60 protected cells from the oxidative stress induced by native THF/n-C 60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C 60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C 60 , resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145073/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceBiomaterialssr
dc.subjectCarbonsr
dc.subjectNanoparticlesr
dc.subjectGamma irradiationsr
dc.subjectCytotoxicitysr
dc.subjectAntioxidantsr
dc.titleInactivation of nanocrystalline C60 cytotoxicity by γ-irradiationsr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractХархаји, Љубица; Ромчевић, Небојша; Раичевић, Невена; Драмићанин, Мирослав; Васиљевић-Радовић, Дана; Николић, Надежда; Тодоровић-Марковић, Биљана; Врањеш-Ђурић, Сања; Трајковић, Владимир; Исаковић, Aлександра; Марковић, Зоран;
dc.rights.holderElseviersr
dc.citation.volume27
dc.citation.issue29
dc.citation.spage5049
dc.citation.epage5058
dc.citation.rankaM21
dc.identifier.pmid16784774
dc.identifier.doi10.1016/j.biomaterials.2006.05.047
dc.identifier.scopus2-s2.0-33745272220
dc.identifier.wos000240167500005
dc.type.versionpublishedVersionsr


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