We investigated the effect of γ-irradiation on the cytotoxicity of pure C 60 solubilized in water by using tetrahydrofuran (THF/n-C 60 or THF/n-C 60 ). In contrast to THF/n-C 60 , its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C 60 protected cells from the oxidative stress induced by native THF/n-C 60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C 60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C 60 , resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.
TY - JOUR
AU - Isaković, Aleksandra
AU - Marković, Zoran M.
AU - Nikolić, Nadežda
AU - Todorović-Marković, Biljana
AU - Vranješ-Đurić, Sanja
AU - Harhaji, Ljubica
AU - Raičević, Nevena
AU - Romčević, Nebojša
AU - Vasiljević-Radović, Dana
AU - Dramićanin, Miroslav
AU - Trajković, Vladimir
PY - 2006
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4120
AB - We investigated the effect of γ-irradiation on the cytotoxicity of pure C 60 solubilized in water by using tetrahydrofuran (THF/n-C 60 or THF/n-C 60 ). In contrast to THF/n-C 60 , its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C 60 protected cells from the oxidative stress induced by native THF/n-C 60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C 60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C 60 , resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.
PB - Elsevier
T2 - Biomaterials
T1 - Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation
VL - 27
IS - 29
SP - 5049
EP - 5058
DO - 10.1016/j.biomaterials.2006.05.047
ER -
@article{
author = "Isaković, Aleksandra and Marković, Zoran M. and Nikolić, Nadežda and Todorović-Marković, Biljana and Vranješ-Đurić, Sanja and Harhaji, Ljubica and Raičević, Nevena and Romčević, Nebojša and Vasiljević-Radović, Dana and Dramićanin, Miroslav and Trajković, Vladimir",
year = "2006",
abstract = "We investigated the effect of γ-irradiation on the cytotoxicity of pure C 60 solubilized in water by using tetrahydrofuran (THF/n-C 60 or THF/n-C 60 ). In contrast to THF/n-C 60 , its γ-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, γ-irradiated THF/n-C 60 protected cells from the oxidative stress induced by native THF/n-C 60 or hydrogen peroxide. The observed biological effects were associated with γ-irradiation-mediated decomposition of THF and subsequent derivatization of the n-C 60 surface. These results for the first time demonstrate γ-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C 60 , resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent.",
publisher = "Elsevier",
journal = "Biomaterials",
title = "Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation",
volume = "27",
number = "29",
pages = "5049-5058",
doi = "10.1016/j.biomaterials.2006.05.047"
}
Isaković, A., Marković, Z. M., Nikolić, N., Todorović-Marković, B., Vranješ-Đurić, S., Harhaji, L., Raičević, N., Romčević, N., Vasiljević-Radović, D., Dramićanin, M.,& Trajković, V.. (2006). Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation. in Biomaterials
Elsevier., 27(29), 5049-5058.
https://doi.org/10.1016/j.biomaterials.2006.05.047
Isaković A, Marković ZM, Nikolić N, Todorović-Marković B, Vranješ-Đurić S, Harhaji L, Raičević N, Romčević N, Vasiljević-Radović D, Dramićanin M, Trajković V. Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation. in Biomaterials. 2006;27(29):5049-5058.
doi:10.1016/j.biomaterials.2006.05.047 .
Isaković, Aleksandra, Marković, Zoran M., Nikolić, Nadežda, Todorović-Marković, Biljana, Vranješ-Đurić, Sanja, Harhaji, Ljubica, Raičević, Nevena, Romčević, Nebojša, Vasiljević-Radović, Dana, Dramićanin, Miroslav, Trajković, Vladimir, "Inactivation of nanocrystalline C60 cytotoxicity by γ-irradiation" in Biomaterials, 27, no. 29 (2006):5049-5058,
https://doi.org/10.1016/j.biomaterials.2006.05.047 . .
, 
