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Cytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulina
dc.creator | Sofrenić, Ivana | |
dc.creator | Anđelković, Boban | |
dc.creator | Todorović, Nina | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Vujisić, Ljubodrag V. | |
dc.creator | Novaković, Miroslav | |
dc.creator | Milosavljević, Slobodan | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2020-12-17T14:36:36Z | |
dc.date.available | 2020-12-17T14:36:36Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4038 | |
dc.description.abstract | Thirteen undescribed 24-methylene lanostane triterpenoids, named polyporenic acids E-M and fomitosides L-O, as well as seventeen known analogues, were isolated from the fruiting bodies of the mushroom Fomitopsis betulina. Their structures were determined using 1D, 2D NMR, IR, and HRESIMS. Fomitoside L and fomitoside N exhibited cytotoxicity against HL60 leukemia cells (IC50 = 15.8 and 23.7 μM, respectively). Among the known compounds, notable cytotoxicities against HL60 leukemia cells and selectivity with respect to MRC-5 healthy cells were noticed for dehydropachymic acid (IC50 = 10.9 μM, SI 8.6), pachymic acid (IC50 = 11.0 μM, SI 9.8), 3-epi-dehydrotumulosic acid (IC50 = 19.9 μM, SI 5.8) and 12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutyryloxy)-24-methyllanosta-8,24 (31)-dien-26-oic acid (IC50 = 19.2 μM, SI 2.2). | en |
dc.publisher | Elsevier | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | en |
dc.rights | restrictedAccess | |
dc.source | Phytochemistry | en |
dc.subject | Fomitopsis betulina | |
dc.subject | Fomitopsidaceae | |
dc.subject | Structural elucidation | |
dc.subject | Lanostane triterpenoid derivatives | |
dc.subject | Cytotoxic activity | |
dc.title | Cytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulina | en |
dc.type | article | en |
dc.rights.license | ARR | en |
dcterms.abstract | Вујисић, Љубодраг; Софренић, Ивана; Тодоровић, Нина; Станојковић, Татјана; Новаковић, Мирослав; Милосављевић, Слободан; Тешевић, Веле; Aнђелковић, Бобан; | |
dc.citation.volume | 181 | |
dc.citation.spage | 112580 | |
dc.citation.rank | M21~ | |
dc.identifier.pmid | 33166752 | |
dc.identifier.doi | 10.1016/j.phytochem.2020.112580 | |
dc.identifier.scopus | 2-s2.0-85095453182 | |
dc.identifier.wos | 000598977700011 | |
dc.type.version | publishedVersion |