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dc.creatorSofrenić, Ivana
dc.creatorAnđelković, Boban
dc.creatorTodorović, Nina
dc.creatorStanojković, Tatjana
dc.creatorVujisić, Ljubodrag V.
dc.creatorNovaković, Miroslav
dc.creatorMilosavljević, Slobodan
dc.creatorTešević, Vele
dc.date.accessioned2020-12-17T14:36:36Z
dc.date.available2020-12-17T14:36:36Z
dc.date.issued2021
dc.identifier.issn0031-9422
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4038
dc.description.abstractThirteen undescribed 24-methylene lanostane triterpenoids, named polyporenic acids E-M and fomitosides L-O, as well as seventeen known analogues, were isolated from the fruiting bodies of the mushroom Fomitopsis betulina. Their structures were determined using 1D, 2D NMR, IR, and HRESIMS. Fomitoside L and fomitoside N exhibited cytotoxicity against HL60 leukemia cells (IC50 = 15.8 and 23.7 μM, respectively). Among the known compounds, notable cytotoxicities against HL60 leukemia cells and selectivity with respect to MRC-5 healthy cells were noticed for dehydropachymic acid (IC50 = 10.9 μM, SI 8.6), pachymic acid (IC50 = 11.0 μM, SI 9.8), 3-epi-dehydrotumulosic acid (IC50 = 19.9 μM, SI 5.8) and 12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutyryloxy)-24-methyllanosta-8,24 (31)-dien-26-oic acid (IC50 = 19.2 μM, SI 2.2).en
dc.publisherElsevier BVen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS//en
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//en
dc.rightsrestrictedAccess
dc.sourcePhytochemistryen
dc.subjectFomitopsis betulina
dc.subjectFomitopsidaceae
dc.subjectStructural elucidation
dc.subjectLanostane triterpenoid derivatives
dc.subjectCytotoxic activity
dc.titleCytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulinaen
dc.typearticleen
dc.rights.licenseARRen
dcterms.abstractВујисић, Љубодраг; Софренић, Ивана; Тодоровић, Нина; Станојковић, Татјана; Новаковић, Мирослав; Милосављевић, Слободан; Тешевић, Веле; Aнђелковић, Бобан;
dc.citation.volume181
dc.citation.spage112580
dc.citation.rankM21~
dc.identifier.pmid33166752
dc.identifier.doi10.1016/j.phytochem.2020.112580
dc.identifier.scopus2-s2.0-85095453182
dc.identifier.wos000598977700011
dc.type.versionpublishedVersion


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