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dc.creatorPonjavic, Marijana
dc.creatorNikolic, Marija S
dc.creatorStevanović, Sanja
dc.creatorNikodinović-Runić, Jasmina
dc.creatorJeremić, Sanja
dc.creatorPavić, Aleksandar
dc.creatorĐongalić, Jasna
dc.date.accessioned2020-12-15T23:55:53Z
dc.date.available2020-12-15T23:55:53Z
dc.date.issued2020
dc.identifier.issn0883-9115
dc.identifier.issn1530-8030
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4019
dc.description.abstractStar-shaped polymers of biodegradable aliphatic polyester, poly(ε-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(ε-caprolactone)s, sPCL, were thoroughly characterized in terms of their degradation under different pH conditions and in respect to their cytotoxicity. The in vitro degradation was performed in phosphate buffer (pH 7.4) and hydrochloric acid solution (pH 1.0) over 5 weeks. Degradation of sPCL films was followed by the weight loss measurements, GPC, FTIR, and AFM analysis. While the most of the samples were stable against the abiotic hydrolysis at pH 7.4 after 5 weeks of degradation, degradation was significantly accelerated in the acidic medium. Degradation rate of polymer films was affected by the polymer architecture and molecular weight. The molecular weight profiles during the degradation revealed random chain scission of the ester bonds indicating bulk degradation mechanism of hydrolysis at pH 7.4, while acidic hydrolysis proceeded through the bulk degradation associated with surface erosion, confirmed by AFM. The in vitro toxicity tests, cytotoxicity applying normal human fibroblasts (MRC5) and embryotoxicity assessment (using zebra fish model, Danio rerio), suggested those polymeric materials as suitable for biomedical application.en
dc.publisherSAGE Publicationsen
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS//
dc.rightsopenAccess
dc.sourceJournal of Bioactive and Compatible Polymersen
dc.subjectStar-shaped PCLs
dc.subjecthydrolysis at different pH
dc.subjectcytotoxycity
dc.subjectembryotoxycity
dc.titleHydrolytic degradation of star-shaped poly(ε-caprolactone)s with different number of arms and their cytotoxic effectsen
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractПавић, Aлександар; Поњавиц, Маријана; Јеремић, Сања; Никодиновић-Рунић, Јасмина; Стевановић, Сања; Николиц, Марија С; Ђонгалић, Јасна;
dc.rights.holderThe Authors
dc.citation.volume35
dc.citation.issue6
dc.citation.spage517
dc.citation.epage537
dc.citation.rankM22~
dc.identifier.doi10.1177/0883911520951826
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/18479/0883911520951826.pdf
dc.identifier.scopus2-s2.0-85090200992
dc.identifier.wos000565911800001
dc.type.versionpublishedVersion


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