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Hydrolytic degradation of star-shaped poly(ε-caprolactone)s with different number of arms and their cytotoxic effects

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2020
0883911520951826.pdf (1.772Mb)
Authors
Ponjavic, Marijana
Nikolic, Marija S
Stevanović, Sanja
Nikodinović-Runić, Jasmina
Jeremić, Sanja
Pavić, Aleksandar
Đongalić, Jasna
Article (Published version)
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Abstract
Star-shaped polymers of biodegradable aliphatic polyester, poly(ε-caprolactone), PCL, with different number of arms (three, four, and six) were synthesized by ring-opening polymerization initiated by multifunctional alcohols used as cores. As potential biomaterials, synthesized star-shaped poly(ε-caprolactone)s, sPCL, were thoroughly characterized in terms of their degradation under different pH conditions and in respect to their cytotoxicity. The in vitro degradation was performed in phosphate buffer (pH 7.4) and hydrochloric acid solution (pH 1.0) over 5 weeks. Degradation of sPCL films was followed by the weight loss measurements, GPC, FTIR, and AFM analysis. While the most of the samples were stable against the abiotic hydrolysis at pH 7.4 after 5 weeks of degradation, degradation was significantly accelerated in the acidic medium. Degradation rate of polymer films was affected by the polymer architecture and molecular weight. The molecular weight profiles during the degradation re...vealed random chain scission of the ester bonds indicating bulk degradation mechanism of hydrolysis at pH 7.4, while acidic hydrolysis proceeded through the bulk degradation associated with surface erosion, confirmed by AFM. The in vitro toxicity tests, cytotoxicity applying normal human fibroblasts (MRC5) and embryotoxicity assessment (using zebra fish model, Danio rerio), suggested those polymeric materials as suitable for biomedical application.

Keywords:
Star-shaped PCLs / hydrolysis at different pH / cytotoxycity / embryotoxycity
Source:
Journal of Bioactive and Compatible Polymers, 2020, 35, 6, 517-537
Publisher:
  • SAGE Publications
Projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200135 (University of Belgrade, Faculty of Technology and Metallurgy) (RS-200135)
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering) (RS-200042)

DOI: 10.1177/0883911520951826

ISSN: 0883-9115; 1530-8030

WoS: 000565911800001

Scopus: 2-s2.0-85090200992
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URI
https://cer.ihtm.bg.ac.rs/handle/123456789/4019
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