dc.creator | Jurišić Dukovski, Bisera | |
dc.creator | Juretić, Marina | |
dc.creator | Bračko, Danka | |
dc.creator | Randjelović, Danijela | |
dc.creator | Savić, Snežana | |
dc.creator | Crespo Moral, Mario | |
dc.creator | Diebold, Yolanda | |
dc.creator | Filipović-Grčić, Jelena | |
dc.creator | Pepić, Ivan | |
dc.creator | Lovrić, Jasmina | |
dc.date.accessioned | 2020-12-12T14:25:21Z | |
dc.date.available | 2020-12-21 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4011 | |
dc.description.abstract | Abstract: Inflammation plays a key role in dry eye disease (DED)
affecting millions of people worldwide. Non-steroidal anti-inflammatory
drugs (NSAIDs) can be used topically to act on the inflammatory component
of DED, but their limited aqueous solubility raises formulation issues.
The aim of this study was development and optimization of functional
cationic nanoemulsions (NEs) for DED treatment, as a formulation approach
to circumvent solubility problems, prolong drug residence at the ocular
surface and stabilize the tear film. Ibuprofen was employed as the model
NSAID, chitosan as the cationic agent, and lecithin as the anionic
surfactant enabling chitosan incorporation. Moreover, lecithin is a
mixture of phospholipids including phosphatidylcholine and
phosphatidylethanolamine, two constituents of the natural tear film
important for its stability. NEs were characterized in terms of droplet
size, polydispersity index, zeta-potential, pH, viscosity, osmolarity,
surface tension, entrapment efficiency, stability, sterilizability and in
vitro release. NEs mucoadhesive properties were tested rheologically
after mixing with mucin dispersion. Biocompatibility was assessed
employing 3D HCE-T cell-based model and ex vivo model using porcine
corneas. The results of our study pointed out the NE formulation with
0.05 % (w/w) chitosan as the lead formulation with physicochemical
properties adequate for ophthalmic application, mucoadhesive character
and excellent biocompatibility. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | Spanish Government Grant RTI2018-094071-B-C21 (MCIU/AEI/FEDER, UE) (YD and MC-M) | sr |
dc.relation | opical nanodelivery systems funded by the University of Zagreb (Z169) | sr |
dc.relation | “Modelling of the Pharmaceutical Spray Drying Process of the Emulsions in Laboratory and Pilot Scale” in collaboration with the industrial partner PLIVA Croatia Ltd. | sr |
dc.rights | embargoedAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | International Journal of Pharmaceutics | sr |
dc.subject | dry eye disease | sr |
dc.subject | nanoemulsion | sr |
dc.subject | NSAID | sr |
dc.subject | chitosan | sr |
dc.subject | lecithin | sr |
dc.title | Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment | en |
dc.type | article | sr |
dc.rights.license | BY-NC-ND | sr |
dcterms.abstract | Рандјеловић, Данијела; Савић, Снежана; Филиповић-Грчић, Јелена; Пепић, Иван; Ловрић, Јасмина; Диеболд, Yоланда; Јуришић Дуковски, Бисера; Јуретић, Марина; Брачко, Данка; Цреспо Морал, Марио; | |
dc.citation.volume | 576 | |
dc.citation.spage | 118979 | |
dc.citation.rank | M21~ | |
dc.description.other | This is the peer-reviewed version of the manuscript: Bisera Jurišić Dukovski et.al., Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment, International Journal of Pharmaceutics, 2020, 576, 118979, DOI: [https://doi.org/10.1016/j.ijpharm.2019.118979] | en |
dc.description.other | The published version: [https://cer.ihtm.bg.ac.rs/handle/123456789/4012] | |
dc.identifier.pmid | 31870964 | |
dc.identifier.doi | 10.1016/j.ijpharm.2019.118979 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs/bitstream/id/18460/IJP-D-19-02365R1_acc_byncnd.pdf | |
dc.identifier.scopus | 2-s2.0-85077471068 | |
dc.identifier.wos | 000512972500015 | |
dc.type.version | acceptedVersion | sr |