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dc.creatorJurišić Dukovski, Bisera
dc.creatorJuretić, Marina
dc.creatorBračko, Danka
dc.creatorRanđelović, Danijela
dc.creatorSavić, Snežana
dc.creatorCrespo Moral, Mario
dc.creatorDiebold, Yolanda
dc.creatorFilipović-Grčić, Jelena
dc.creatorPepić, Ivan
dc.creatorLovrić, Jasmina
dc.date.accessioned2020-12-12T14:25:21Z
dc.date.available2020-12-21
dc.date.issued2020
dc.identifier.issn0378-5173
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/4011
dc.description.abstractAbstract: Inflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular surface and stabilize the tear film. Ibuprofen was employed as the model NSAID, chitosan as the cationic agent, and lecithin as the anionic surfactant enabling chitosan incorporation. Moreover, lecithin is a mixture of phospholipids including phosphatidylcholine and phosphatidylethanolamine, two constituents of the natural tear film important for its stability. NEs were characterized in terms of droplet size, polydispersity index, zeta-potential, pH, viscosity, osmolarity, surface tension, entrapment efficiency, stability, sterilizability and in vitro release. NEs mucoadhesive properties were tested rheologically after mixing with mucin dispersion. Biocompatibility was assessed employing 3D HCE-T cell-based model and ex vivo model using porcine corneas. The results of our study pointed out the NE formulation with 0.05 % (w/w) chitosan as the lead formulation with physicochemical properties adequate for ophthalmic application, mucoadhesive character and excellent biocompatibility.en
dc.language.isoensr
dc.publisherElsevier BVsr
dc.relationSpanish Government Grant RTI2018-094071-B-C21 (MCIU/AEI/FEDER, UE) (YD and MC-M)sr
dc.relationopical nanodelivery systems funded by the University of Zagreb (Z169)sr
dc.relation“Modelling of the Pharmaceutical Spray Drying Process of the Emulsions in Laboratory and Pilot Scale” in collaboration with the industrial partner PLIVA Croatia Ltd.sr
dc.rightsembargoedAccesssr
dc.sourceInternational Journal of Pharmaceuticssr
dc.subjectdry eye diseasesr
dc.subjectnanoemulsionsr
dc.subjectNSAIDsr
dc.subjectchitosansr
dc.subjectlecithinsr
dc.titleFunctional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatmenten
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractРандјеловић, Данијела; Савић, Снежана; Филиповић-Грчић, Јелена; Пепић, Иван; Ловрић, Јасмина; Диеболд, Yоланда; Јуришић Дуковски, Бисера; Јуретић, Марина; Брачко, Данка; Цреспо Морал, Марио;
dc.citation.volume576
dc.citation.spage118979
dc.citation.rankM21~
dc.description.otherThis is the peer-reviewed version of the manuscript: Bisera Jurišić Dukovski et.al., Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment, International Journal of Pharmaceutics, 2020, 576, 118979, DOI: [https://doi.org/10.1016/j.ijpharm.2019.118979]en
dc.description.otherThe published version: [https://cer.ihtm.bg.ac.rs/handle/123456789/4012]
dc.identifier.pmid31870964
dc.identifier.doi10.1016/j.ijpharm.2019.118979
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/18460/IJP-D-19-02365R1_acc_byncnd.pdf
dc.identifier.scopus2-s2.0-85077471068
dc.identifier.wos000512972500015
dc.type.versionacceptedVersionsr


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