Приказ основних података о документу
Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
dc.creator | Todorović, Nina | |
dc.creator | Stefanović, Milutin | |
dc.creator | Tinant, Bernard | |
dc.creator | Declercq, Jean-Paul | |
dc.creator | Makler, Michael T | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2020-12-08T11:48:04Z | |
dc.date.available | 2020-12-08T11:48:04Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0039-128X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3995 | |
dc.description.abstract | Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5e~- and 5~3-cholestan3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5~3-cholestane3et,3~5-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds" were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC5o = 155 nM | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | Serbian Academy of Sciences and Arts, Research Fund of Serbia for financial support (grant 02E4) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Steroids | sr |
dc.subject | gem-dihydroperoxide | sr |
dc.subject | peroxide | sr |
dc.subject | tetraoxane | sr |
dc.subject | molecular mechanics | sr |
dc.subject | antimalarial activity | sr |
dc.title | Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Стефановић, Милутин; Децлерцq, Јеан-Паул; Тодоровић, Нина; Шолаја, Богдан; Маклер, Мицхаел Т; Тинант, Бернард; | |
dc.rights.holder | Elsevier Science Inc. | sr |
dc.citation.volume | 61 | |
dc.citation.issue | 12 | |
dc.citation.spage | 688 | |
dc.citation.epage | 696 | |
dc.identifier.pmid | 8987137 | |
dc.identifier.doi | 10.1016/S0039-128X(96)00203-6 | |
dc.identifier.scopus | 2-s2.0-0030477376 | |
dc.identifier.wos | A1996VY35500003 | |
dc.type.version | publishedVersion | sr |