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dc.creatorAdžić, Miroslav
dc.creatorNićiforović, Ana
dc.creatorVucić, Vesna
dc.creatorNešković-Konstantinović, Zora
dc.creatorSpasić, Snežana
dc.creatorJones, David
dc.creatorRadojčić, Marija
dc.creatorSpasić, Mihajlo
dc.date.accessioned2020-12-03T14:45:04Z
dc.date.available2020-12-03T14:45:04Z
dc.date.issued2006
dc.identifier.issn1351-0002
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3965
dc.description.abstractThere is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.en
dc.language.isoensr
dc.publisherManey Publishingsr
dc.relationMinistry for Science and Environmental Protection, Republic of Serbia and Montenegrosr
dc.rightsrestrictedAccesssr
dc.sourceRedox Reportsr
dc.subjectNF-κBsr
dc.subjectMn-SODsr
dc.subjectCATsr
dc.subjectbreast cancersr
dc.titleSystemic NF-kappaB activation in blood cells of breast cancer patientsen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractНешковић-Константиновић, Зора; Спасић, Михајло; Радојчић, Марија; Јонес, Давид; Спасић, Снежана; Aджић, Мирослав; Нићифоровић, Aна; Вуцић, Весна;
dc.citation.volume11
dc.citation.issue1
dc.citation.spage39
dc.citation.spage44
dc.citation.rankM23
dc.identifier.pmid16571274
dc.identifier.doi10.1179/135100006X101002
dc.identifier.scopus2-s2.0-33746361222
dc.identifier.wos000236947500005
dc.type.versionpublishedVersionsr


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