Systemic NF-kappaB activation in blood cells of breast cancer patients
Само за регистроване кориснике
2006
Аутори
Adžić, MiroslavNićiforović, Ana
Vucić, Vesna
Nešković-Konstantinović, Zora
Spasić, Snežana
Jones, David
Radojčić, Marija
Spasić, Mihajlo
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase ...(CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.
Кључне речи:
NF-κB / Mn-SOD / CAT / breast cancerИзвор:
Redox Report, 2006, 11, 1, 39-Издавач:
- Maney Publishing
Финансирање / пројекти:
- Ministry for Science and Environmental Protection, Republic of Serbia and Montenegro
DOI: 10.1179/135100006X101002
ISSN: 1351-0002
PubMed: 16571274
WoS: 000236947500005
Scopus: 2-s2.0-33746361222
Институција/група
IHTMTY - JOUR AU - Adžić, Miroslav AU - Nićiforović, Ana AU - Vucić, Vesna AU - Nešković-Konstantinović, Zora AU - Spasić, Snežana AU - Jones, David AU - Radojčić, Marija AU - Spasić, Mihajlo PY - 2006 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3965 AB - There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells. PB - Maney Publishing T2 - Redox Report T1 - Systemic NF-kappaB activation in blood cells of breast cancer patients VL - 11 IS - 1 SP - 39 SP - 44 DO - 10.1179/135100006X101002 ER -
@article{ author = "Adžić, Miroslav and Nićiforović, Ana and Vucić, Vesna and Nešković-Konstantinović, Zora and Spasić, Snežana and Jones, David and Radojčić, Marija and Spasić, Mihajlo", year = "2006", abstract = "There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.", publisher = "Maney Publishing", journal = "Redox Report", title = "Systemic NF-kappaB activation in blood cells of breast cancer patients", volume = "11", number = "1", pages = "39-44", doi = "10.1179/135100006X101002" }
Adžić, M., Nićiforović, A., Vucić, V., Nešković-Konstantinović, Z., Spasić, S., Jones, D., Radojčić, M.,& Spasić, M.. (2006). Systemic NF-kappaB activation in blood cells of breast cancer patients. in Redox Report Maney Publishing., 11(1), 39. https://doi.org/10.1179/135100006X101002
Adžić M, Nićiforović A, Vucić V, Nešković-Konstantinović Z, Spasić S, Jones D, Radojčić M, Spasić M. Systemic NF-kappaB activation in blood cells of breast cancer patients. in Redox Report. 2006;11(1):39. doi:10.1179/135100006X101002 .
Adžić, Miroslav, Nićiforović, Ana, Vucić, Vesna, Nešković-Konstantinović, Zora, Spasić, Snežana, Jones, David, Radojčić, Marija, Spasić, Mihajlo, "Systemic NF-kappaB activation in blood cells of breast cancer patients" in Redox Report, 11, no. 1 (2006):39, https://doi.org/10.1179/135100006X101002 . .