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dc.creatorOreščanin, Zorana
dc.creatorMilovanović, Slobodan R.
dc.creatorSpasić, Snežana
dc.creatorJones, David
dc.creatorSpasić, Mihajlo
dc.date.accessioned2020-12-02T12:00:08Z
dc.date.available2020-12-02T12:00:08Z
dc.date.issued2007
dc.identifier.issn1734-1140
dc.identifier.issn2299-5684
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3938
dc.description.abstractThe conversion of nitric oxide (NO ) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth musclen
dc.language.isoensr
dc.publisherSpringersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143034/RS//sr
dc.rightsrestrictedAccesssr
dc.sourcePharmacological Reportsr
dc.subjectEndotheliumsr
dc.subjectHypertensionsr
dc.subjectMesenteric arterysr
dc.subjectMnSODsr
dc.subjectSodium nitroprussidesr
dc.titleDifferent responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congenersen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractСпасић, Снежана; Орешчанин, Зорана; Спасић, Михајло; Јонес, Давид; Миловановић, Слободан Р.;
dc.rights.holderSpringersr
dc.citation.volume59
dc.citation.spage315
dc.citation.epage322
dc.citation.rankM22
dc.identifier.scopus2-s2.0-34548131592
dc.identifier.wos000248614800009
dc.type.versionpublishedVersionsr


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