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dc.creatorNešić, Maja D.
dc.creatorDučić, Tanja
dc.creatorLiang, Xinyue
dc.creatorAlgarra, Manuel
dc.creatorMi, Lan
dc.creatorKorićanac, Lela
dc.creatorŽakula, Jelena
dc.creatorKop, Tatjana
dc.creatorBjelaković, Mira
dc.creatorMitrović, Aleksandra
dc.creatorGojgić-Cvijović, Gordana
dc.creatorStepić, Milutin
dc.creatorPetković, Marijana
dc.date.accessioned2020-12-01T06:54:05Z
dc.date.available2020-12-01T06:54:05Z
dc.date.issued2020
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003 (web)
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3891
dc.description.abstractAbstract Objects of the present study are improved fullerene C60 drug carrier properties trough encapsulation by microbial polysaccharides, levan (LEV), pullulan (PUL), and their hydrophobized cholesterol-derivatives (CHL and CHP), that show better interaction with cancer cells. The zeta potential, polydispersity index, and the diameter of particles were determined, and their cytotoxicity against three cancer cell lines were tested. Biochemical changes in HeLa cells are analyzed by synchrotron radiation (SR) FTIR spectro-microscopy combined with the principal component analysis (PCA). The most significant changes occur in HeLa cells treated with LEV-C60 and correspond to the changes in the protein region, i.e. Amide Iband, and the changes in the structure of lipid bodies and membrane fluidity are evident. The highest cytotoxicity was also induced by LEV-C60. In HeLa cells, cytotoxicity could not be strictly associated with biochemical changes in lipids, proteins and nucleic acids, but these findings are significant contribution to the study of the mechanism of interaction of C60-based nanoparticles with cellular biomolecules. In conclusion, LEV, PUL, CHL, and CHP enhanced fullerene C60potential to be used as target drug delivery system with the ability to induce specific intracellular changes in HeLa cancer cells.en
dc.language.isoensr
dc.publisherElseviersr
dc.relationAgência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação (M1420-01-0145-FEDER-000005)sr
dc.relationMinistry of Science and Technology of the People's Republic of China (SINO-SERBIA2018002)sr
dc.relationMadeira 14-20 Program (RAM-M1420-01-0145-FEDER-000008)sr
dc.relationSerbian-Chinese bilateral project (451-00-478/2018-09/16)sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//sr
dc.relationALBA Synchrotron (Grant No. 2019093770)sr
dc.relationFundação para a Ciência e a Tecnologia (PEstOE/QUI/UI0674/2019)sr
dc.relationFundação para a Ciência e a Tecnologia (INNOINDIGO/0001/2015)sr
dc.relationFundação para a Ciência e a Tecnologia (UID/MAT/00006/2019)sr
dc.relationMinisterio de Ciencia, Innovación y Universidades (RTI2018-099668-BC22)sr
dc.relationJunta de Andalucía and FEDER funds (UMA18-FEDERJA-126)sr
dc.rightsrestrictedAccesssr
dc.sourceInternational Journal of Biological Macromoleculessr
dc.subjectPullulan-C60sr
dc.subjectLevan-C60sr
dc.subjectSynchrotron radiation FTIR spectro-microscopysr
dc.titleSR-FTIR spectro-microscopic interaction study of biochemical changes in HeLa cells induced by Levan-C60, Pullulan-C60, and their cholesterol-derivativesen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractНешић, Маја, Д.; Бјелаковић, Мира С.; Дучић, Тања; Aлгарра, Мануел; Коп, Татјана Ј.; Корићанац, Лела; Ми, Лан; Петковић, Маријана; Лианг, Xинyуе; Митровић, Aлександра; Гојгић Цвијовић, Гордана Д.; Степић, Милутин; Жакула, Јелена;
dc.rights.holderElseviersr
dc.citation.volume165
dc.citation.issueB
dc.citation.spage2541
dc.citation.epage2549
dc.citation.rankaM21~
dc.identifier.doi10.1016/j.ijbiomac.2020.10.141
dc.identifier.scopus2-s2.0-85094207129
dc.identifier.wos000600773500088
dc.type.versionpublishedVersionsr


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