Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions
Regulacija ćelijskih procesa reaktivnim vrstama kiseonika i azot monoksida - Mehanizmi reakcija
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Приказ свих података о документуАпстракт
Recent evidence revealed that reactive oxygen species (ROS) such assuperoxide (O ) and hydrogen peroxide (H O ), which are conventionally2.-22viewed as unwanted and toxic by-products of life in an aerobic environment,have physiological roles. Appraisal of the roles of reactive NO species(RNOS), such as nitrosonium (NO ) and nitroxyl (NO ) ions, peroxynitrite+-(OONO ), and higher nitrogen oxides (NO ) in NO mediated processes, is-xgrowing at a rapid rate. ROS and RNOS may evoke a variety of cellularresponses, ranging from major changes in mammalian cell gene expressionto apoptotic death. The greater prevalence and reactivity of thiols over otherbiological nucleophiles makes them targets for both ROS and RNOS. Anyessential protein containing cysteine residue that is strategically located ateither active or allosteric site should be considered as a target for regulationby ROS and/or RNOS. Candidate molecules include proteins that are themselves in...volved in signal transduction processes, ion channels, receptors,G-proteins, protein-kinases, protein phosphatases, and transcription-activatingfactors. In this paper the mechanisms of generation of ROS and RNOS andtheir reactions with thiols are briefly described. The regulation of cellprocesses by ROS and RNOS is illustrated by the interference of ROS andRNOS effects with receptor tyrosine kinases signaling.
Кључне речи:
NO-dismutation / Reactive oxygen species (ROS) / Reactive NO species (RNOS) / Redox signaling / ThiolsИзвор:
Iugoslav. Physiol. Pharmacol. Acta, 1998, 34, 463-477Издавач:
- Yugoslav Union of Physiological Societies
Институција/група
IHTMTY - JOUR AU - Niketić, Vesna AU - Stojanović, Srđan AU - Spasić, Mihajlo PY - 1998 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3887 AB - Recent evidence revealed that reactive oxygen species (ROS) such assuperoxide (O ) and hydrogen peroxide (H O ), which are conventionally2.-22viewed as unwanted and toxic by-products of life in an aerobic environment,have physiological roles. Appraisal of the roles of reactive NO species(RNOS), such as nitrosonium (NO ) and nitroxyl (NO ) ions, peroxynitrite+-(OONO ), and higher nitrogen oxides (NO ) in NO mediated processes, is-xgrowing at a rapid rate. ROS and RNOS may evoke a variety of cellularresponses, ranging from major changes in mammalian cell gene expressionto apoptotic death. The greater prevalence and reactivity of thiols over otherbiological nucleophiles makes them targets for both ROS and RNOS. Anyessential protein containing cysteine residue that is strategically located ateither active or allosteric site should be considered as a target for regulationby ROS and/or RNOS. Candidate molecules include proteins that are themselves involved in signal transduction processes, ion channels, receptors,G-proteins, protein-kinases, protein phosphatases, and transcription-activatingfactors. In this paper the mechanisms of generation of ROS and RNOS andtheir reactions with thiols are briefly described. The regulation of cellprocesses by ROS and RNOS is illustrated by the interference of ROS andRNOS effects with receptor tyrosine kinases signaling. PB - Yugoslav Union of Physiological Societies T2 - Iugoslav. Physiol. Pharmacol. Acta T1 - Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions T1 - Regulacija ćelijskih procesa reaktivnim vrstama kiseonika i azot monoksida - Mehanizmi reakcija VL - 34 SP - 463 EP - 477 UR - https://hdl.handle.net/21.15107/rcub_cer_3887 ER -
@article{ author = "Niketić, Vesna and Stojanović, Srđan and Spasić, Mihajlo", year = "1998", abstract = "Recent evidence revealed that reactive oxygen species (ROS) such assuperoxide (O ) and hydrogen peroxide (H O ), which are conventionally2.-22viewed as unwanted and toxic by-products of life in an aerobic environment,have physiological roles. Appraisal of the roles of reactive NO species(RNOS), such as nitrosonium (NO ) and nitroxyl (NO ) ions, peroxynitrite+-(OONO ), and higher nitrogen oxides (NO ) in NO mediated processes, is-xgrowing at a rapid rate. ROS and RNOS may evoke a variety of cellularresponses, ranging from major changes in mammalian cell gene expressionto apoptotic death. The greater prevalence and reactivity of thiols over otherbiological nucleophiles makes them targets for both ROS and RNOS. Anyessential protein containing cysteine residue that is strategically located ateither active or allosteric site should be considered as a target for regulationby ROS and/or RNOS. Candidate molecules include proteins that are themselves involved in signal transduction processes, ion channels, receptors,G-proteins, protein-kinases, protein phosphatases, and transcription-activatingfactors. In this paper the mechanisms of generation of ROS and RNOS andtheir reactions with thiols are briefly described. The regulation of cellprocesses by ROS and RNOS is illustrated by the interference of ROS andRNOS effects with receptor tyrosine kinases signaling.", publisher = "Yugoslav Union of Physiological Societies", journal = "Iugoslav. Physiol. Pharmacol. Acta", title = "Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions, Regulacija ćelijskih procesa reaktivnim vrstama kiseonika i azot monoksida - Mehanizmi reakcija", volume = "34", pages = "463-477", url = "https://hdl.handle.net/21.15107/rcub_cer_3887" }
Niketić, V., Stojanović, S.,& Spasić, M.. (1998). Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions. in Iugoslav. Physiol. Pharmacol. Acta Yugoslav Union of Physiological Societies., 34, 463-477. https://hdl.handle.net/21.15107/rcub_cer_3887
Niketić V, Stojanović S, Spasić M. Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions. in Iugoslav. Physiol. Pharmacol. Acta. 1998;34:463-477. https://hdl.handle.net/21.15107/rcub_cer_3887 .
Niketić, Vesna, Stojanović, Srđan, Spasić, Mihajlo, "Regulation of cell processes by rective oxygen and nitric oxide species - Mechanisms of reactions" in Iugoslav. Physiol. Pharmacol. Acta, 34 (1998):463-477, https://hdl.handle.net/21.15107/rcub_cer_3887 .