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dc.creatorNikolić-Kokić, Aleksandra
dc.creatorStević, Zorica
dc.creatorStojanović, Srđan
dc.creatorBlagojević, Duško
dc.creatorJones, David
dc.creatorPavlović, Sanja
dc.creatorNikrtić, Vesna
dc.creatorApostolski, Slobodan
dc.creatorSpasić, Mihajlo
dc.date.accessioned2020-11-28T15:40:41Z
dc.date.available2020-11-28T15:40:41Z
dc.date.issued2005
dc.identifier.issn1351-0002
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3868
dc.description.abstractRecent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis of sporadic amyotrophic lateral sclerosis (SALS). We measured significantly higherconcentrations of uric acid and thiol group-containing molecules (R–SH groups) in thecerebrospinal fluid (CSF) from SALS patients compared to controls. The above factors, togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe formation of the dinitrosyl iron complex, capable of NO•bio-transformation. Thus, weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS patients (when compared to control subjects) but no activity corresponding to Mn-SOD inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients.en
dc.language.isoensr
dc.publisherManey Publishingsr
dc.relationMinistry for Science,Technology and Development of Serbia (grant 1669)sr
dc.relationMinistry for Science,Technology and Development of Serbia (grant 1559)sr
dc.rightsrestrictedAccesssr
dc.sourceRedox Reportsr
dc.subjectDinitrosyl iron complexsr
dc.subjecturic acidsr
dc.subjectnitric oxidesr
dc.subjectcerebrospinal fluidsr
dc.subjectamyotrophic lateralsclerosissr
dc.titleBiotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patientsen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractПавловић, Сања; Благојевић, Душко; Николић-Кокић, Aлександра; Стевиц, Зорица; Стојановић, Срђан; Јонес, Давид; Спасић, Михајло; Aпостолски, Слободан; Никртић, Весна;
dc.rights.holderW. S. Maney & Son Ltdsr
dc.citation.volume10
dc.citation.issue5
dc.citation.spage265
dc.citation.epage270
dc.citation.rankM23
dc.identifier.pmid16354415
dc.identifier.doi10.1179/135100005X70242
dc.identifier.scopus2-s2.0-33646711195
dc.identifier.wos000234389600004
dc.type.versionpublishedVersionsr


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