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dc.creatorAvramov Ivić, Milka
dc.creatorPetrović, Slobodan D.
dc.creatorVonmoos, F.
dc.creatorMijin, Dušan
dc.creatorŽivković, Predrag M.
dc.creatorDrljevic, K. M.
dc.date.accessioned2019-01-30T17:16:54Z
dc.date.available2019-01-30T17:16:54Z
dc.date.issued2008
dc.identifier.issn1023-1935
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/377
dc.description.abstractThe aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.en
dc.publisherPleiades Publishing Inc, Moscow
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142063/RS//
dc.rightsrestrictedAccess
dc.sourceRussian Journal of Electrochemistry
dc.subjectcommercial clarithromycinen
dc.subjectgold electrodeen
dc.subjectcyclic voltammetryen
dc.subjectreproductive anodic peaken
dc.subjectFTIR of bulk of electrolyteen
dc.titleThe electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВонмоос, Ф.; Дрљевиц, К. М.; Зивковиц, П. М.; Мијин, Д. З.; Петровић, Слободан Д.; Aврамов Ивић, Милка;
dc.citation.volume44
dc.citation.issue8
dc.citation.spage931
dc.citation.epage936
dc.citation.other44(8): 931-936
dc.citation.rankM23
dc.identifier.doi10.1134/S1023193508080089
dc.identifier.rcubConv_2412
dc.identifier.scopus2-s2.0-53949111011
dc.identifier.wos000258844300008
dc.type.versionpublishedVersion


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