The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating dis...appearance of lactone structure and changes of carbonyl group at position 9.
Keywords:
commercial clarithromycin / gold electrode / cyclic voltammetry / reproductive anodic peak / FTIR of bulk of electrolyte
Source:
Russian Journal of Electrochemistry, 2008, 44, 8, 931-936
TY - JOUR
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Vonmoos, F.
AU - Mijin, Dušan
AU - Živković, Predrag M.
AU - Drljevic, K. M.
PY - 2008
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/377
AB - The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.
PB - Pleiades Publishing Inc, Moscow
T2 - Russian Journal of Electrochemistry
T1 - The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes
VL - 44
IS - 8
SP - 931
EP - 936
DO - 10.1134/S1023193508080089
ER -
@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljevic, K. M.",
year = "2008",
abstract = "The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.",
publisher = "Pleiades Publishing Inc, Moscow",
journal = "Russian Journal of Electrochemistry",
title = "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes",
volume = "44",
number = "8",
pages = "931-936",
doi = "10.1134/S1023193508080089"
}
Avramov Ivić, M., Petrović, S. D., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljevic, K. M.. (2008). The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry
Pleiades Publishing Inc, Moscow., 44(8), 931-936.
https://doi.org/10.1134/S1023193508080089
Avramov Ivić M, Petrović SD, Vonmoos F, Mijin D, Živković PM, Drljevic KM. The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry. 2008;44(8):931-936.
doi:10.1134/S1023193508080089 .
Avramov Ivić, Milka, Petrović, Slobodan D., Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljevic, K. M., "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes" in Russian Journal of Electrochemistry, 44, no. 8 (2008):931-936,
https://doi.org/10.1134/S1023193508080089 . .
