The reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is ...more reactive than clarithromycin, although similar changes in their molecular structures were observed.
TY - JOUR
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Mijin, Dušan
AU - Vanmoos, F.
AU - Orlovic, D. Z.
AU - Marjanovic, D. Z.
AU - Radovic, V. V.
PY - 2008
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/375
AB - The reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is more reactive than clarithromycin, although similar changes in their molecular structures were observed.
PB - Oxford : Pergamon-Elsevier Science Ltd
T2 - Electrochimica Acta
T1 - The electrochemical behavior of erythromycin A on a gold electrode
VL - 54
IS - 2
SP - 649
EP - 654
DO - 10.1016/j.electacta.2008.07.010
ER -
@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Vanmoos, F. and Orlovic, D. Z. and Marjanovic, D. Z. and Radovic, V. V.",
year = "2008",
abstract = "The reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is more reactive than clarithromycin, although similar changes in their molecular structures were observed.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "The electrochemical behavior of erythromycin A on a gold electrode",
volume = "54",
number = "2",
pages = "649-654",
doi = "10.1016/j.electacta.2008.07.010"
}
Avramov Ivić, M., Petrović, S. D., Mijin, D., Vanmoos, F., Orlovic, D. Z., Marjanovic, D. Z.,& Radovic, V. V.. (2008). The electrochemical behavior of erythromycin A on a gold electrode. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 54(2), 649-654.
https://doi.org/10.1016/j.electacta.2008.07.010
Avramov Ivić M, Petrović SD, Mijin D, Vanmoos F, Orlovic DZ, Marjanovic DZ, Radovic VV. The electrochemical behavior of erythromycin A on a gold electrode. in Electrochimica Acta. 2008;54(2):649-654.
doi:10.1016/j.electacta.2008.07.010 .
Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Vanmoos, F., Orlovic, D. Z., Marjanovic, D. Z., Radovic, V. V., "The electrochemical behavior of erythromycin A on a gold electrode" in Electrochimica Acta, 54, no. 2 (2008):649-654,
https://doi.org/10.1016/j.electacta.2008.07.010 . .
