Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
TY - CONF
AU - Mrđan, Gorana
AU - Verbić, Tatjana
AU - Marković, Olivera
AU - Matijević, Borko
AU - Vaštag, Đenđi
AU - Apostolov, Suzana
PY - 2020
UR - http://savremenimaterijali.info/
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3688
AB - Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
PB - Academy of Sciences and Arts of the Republic of Srpska
C3 - 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.
T1 - Determination of ionization constants of selected monocarbohydrazone derivatites
SP - 50
EP - 50
UR - https://hdl.handle.net/21.15107/rcub_cer_3688
ER -
@conference{
author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana",
year = "2020",
abstract = "Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.",
publisher = "Academy of Sciences and Arts of the Republic of Srpska",
journal = "13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.",
title = "Determination of ionization constants of selected monocarbohydrazone derivatites",
pages = "50-50",
url = "https://hdl.handle.net/21.15107/rcub_cer_3688"
}
Mrđan, G., Verbić, T., Marković, O., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatites. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.
Academy of Sciences and Arts of the Republic of Srpska., 50-50.
https://hdl.handle.net/21.15107/rcub_cer_3688
Mrđan G, Verbić T, Marković O, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatites. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.. 2020;:50-50.
https://hdl.handle.net/21.15107/rcub_cer_3688 .
Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatites" in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020. (2020):50-50,
https://hdl.handle.net/21.15107/rcub_cer_3688 .
