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dc.creatorBatinić, Petar M.
dc.creatorĐorđević, Verica B.
dc.creatorStevanović, Sanja
dc.creatorBalanč, Bojana D.
dc.creatorMarković, Smilja
dc.creatorLuković, Nevena D.
dc.creatorMijin, Dušan
dc.creatorBugarski, Branko
dc.date.accessioned2020-09-22T08:31:12Z
dc.date.available2021-07-18
dc.date.issued2020
dc.identifier.issn1773-2247
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3682
dc.description.abstractIn this study, development of folic acid-loaded liposomes using a basic amino acid, histidine as a solubilizing agent for folic acid was presented, which tackled the poor solubility of this vitamin. The effect of the liposomal membrane modifiers, cholesterol and SPAN 20 on the characteristics of the final formulations was examined. Liposomes prepared from a commercially available purified soybean lecithin (Phospholipon 90G) by proliposome method were between 503 and 877 nm in average diameter, where cholesterol induced enlargement and SPAN.20 reduction of vesicles. High encapsulation efficiency of 84% and drug loading of 0.123 mg g−1 were achieved, irrespective to the composition. According to AFM images, folic acid-loaded liposomes of a fraction with a nano size were flattened compared to globular empty liposomes. FTIR analysis revealed possible interactions between phospholipids and histidine, while DSC study suggested interactions between folic acid and lipids during heating. Release study done by a Franz diffusion cell showed prolonged release of folic acid from liposomes and the release rate was determined by folic acid solubility.en
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//sr
dc.rightsembargoedAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Drug Delivery Science and Technologysr
dc.subjectEncapsulation efficiencysr
dc.subjectPhospholipon 90Gsr
dc.subjectCholesterolsr
dc.subjectSPAN.20sr
dc.subjectFranz diffusion cellsr
dc.titleFormulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitaminen
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractЂорђевић, Верица Б.; Луковић, Невена Д.; Баланч, Бојана Д.; Батинић, Петар М.; Стевановић, Сања; Бугарски, Бранко; Марковић, Смиља; Мијин, Душан;
dc.rights.holderElseviersr
dc.citation.volume59
dc.citation.spage101920
dc.citation.rankM22~
dc.description.otherThis is the peer-reviewed version of the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: [https://doi.org/10.1016/j.jddst.2020.101920]
dc.description.otherThe published version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3681]
dc.identifier.doi10.1016/j.jddst.2020.101920
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/17354/novel_liposomes_j.jddst.2020.101920.pdf
dc.identifier.scopus2-s2.0-85088379189
dc.identifier.wos000572445500003
dc.type.versionacceptedVersionsr


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