ЦЕР - Централни Репозиторијум ИХТМ-а
Институт за хемију, технологију и металургију
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ЦЕР - Централни репозиторијум ИХТМ-а
  • IHTM
  • Radovi istraživača / Researchers' publications
  • Преглед рада
  •   ЦЕР - Централни репозиторијум ИХТМ-а
  • IHTM
  • Radovi istraživača / Researchers' publications
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives

Само за регистроване кориснике
2007
Аутори
Gaši, K.M.P.
Brenesel, M.Dj.D.
Djurendić, E.A.
Sakač, Marija
Čanadi, J.J.
Daljev, J.J.
Armbruster, T.
Andrić, Silvana
Sladić, Dušan
Božić, Tatjana T.
Novaković, Irena
Juranić, Zorica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Starting from dehydroepiandrosterone (1) 17-picolyl (2), 17-picolinylidene (7), 17-picolinylidene-16-one (10 and 11), and 17-picolyl-16-one (15) derivatives of androst-5-ene were synthesized in one, two, four and five steps respectively. By the Oppenauer oxidation or dehydration of 2, 7, 10, and 11 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), the corresponding A and B ring modified derivatives 3, 5, 6, 8, 9, and 12-14 were obtained. The structure of 2 was unambiguously proved by the appropriate X-ray structural analysis. Compounds 3, 5, 9, 12-14 showed inhibitory activity against the enzyme aromatase. Antibacterial activity, toxicity to brine shrimp Artemia salina, antitumor activity against three tumor cell lines (human cervix carcinoma HeLa cells, human melanoma FemX cells, and human myelogenous leukemia K562 cells) and toxicity against peripheral blood mononuclear cells were evaluated. Three tested compounds, namely 11, 13, and 15, showed strong activity against all three c...ell lines, the IC50 values being in the range of 4-10 μM.

Кључне речи:
Androst-5-ene derivatives / Antibacterial activity / Antitumor activity / Aromatase inhibition / Picolyl and picolinylidene derivatives / X-ray analysis
Извор:
Steroids, 2007, 72, 1, 31-40
Издавач:
  • Elsevier Science Inc, New York
Пројекти:
  • Синтеза и физичко-хемијска испитивања одабраних органских једињења од потенцијалног фармаколошког значаја (RS-142052)

DOI: 10.1016/j.steroids.2006.10.002

ISSN: 0039-128X

PubMed: 17118415

WoS: 000243861100004

Scopus: 2-s2.0-33846020540
[ Google Scholar ]
30
29
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/366
Колекције
  • Radovi istraživača / Researchers' publications
Институција
IHTM
TY  - JOUR
AU  - Gaši, K.M.P.
AU  - Brenesel, M.Dj.D.
AU  - Djurendić, E.A.
AU  - Sakač, Marija
AU  - Čanadi, J.J.
AU  - Daljev, J.J.
AU  - Armbruster, T.
AU  - Andrić, Silvana
AU  - Sladić, Dušan
AU  - Božić, Tatjana T.
AU  - Novaković, Irena
AU  - Juranić, Zorica
PY  - 2007
UR  - http://cer.ihtm.bg.ac.rs/handle/123456789/366
AB  - Starting from dehydroepiandrosterone (1) 17-picolyl (2), 17-picolinylidene (7), 17-picolinylidene-16-one (10 and 11), and 17-picolyl-16-one (15) derivatives of androst-5-ene were synthesized in one, two, four and five steps respectively. By the Oppenauer oxidation or dehydration of 2, 7, 10, and 11 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), the corresponding A and B ring modified derivatives 3, 5, 6, 8, 9, and 12-14 were obtained. The structure of 2 was unambiguously proved by the appropriate X-ray structural analysis. Compounds 3, 5, 9, 12-14 showed inhibitory activity against the enzyme aromatase. Antibacterial activity, toxicity to brine shrimp Artemia salina, antitumor activity against three tumor cell lines (human cervix carcinoma HeLa cells, human melanoma FemX cells, and human myelogenous leukemia K562 cells) and toxicity against peripheral blood mononuclear cells were evaluated. Three tested compounds, namely 11, 13, and 15, showed strong activity against all three cell lines, the IC50 values being in the range of 4-10 μM.
PB  - Elsevier Science Inc, New York
T2  - Steroids
T1  - Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives
VL  - 72
IS  - 1
SP  - 31
EP  - 40
DO  - 10.1016/j.steroids.2006.10.002
ER  - 
@article{
author = "Gaši, K.M.P. and Brenesel, M.Dj.D. and Djurendić, E.A. and Sakač, Marija and Čanadi, J.J. and Daljev, J.J. and Armbruster, T. and Andrić, Silvana and Sladić, Dušan and Božić, Tatjana T. and Novaković, Irena and Juranić, Zorica",
year = "2007",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/366",
abstract = "Starting from dehydroepiandrosterone (1) 17-picolyl (2), 17-picolinylidene (7), 17-picolinylidene-16-one (10 and 11), and 17-picolyl-16-one (15) derivatives of androst-5-ene were synthesized in one, two, four and five steps respectively. By the Oppenauer oxidation or dehydration of 2, 7, 10, and 11 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), the corresponding A and B ring modified derivatives 3, 5, 6, 8, 9, and 12-14 were obtained. The structure of 2 was unambiguously proved by the appropriate X-ray structural analysis. Compounds 3, 5, 9, 12-14 showed inhibitory activity against the enzyme aromatase. Antibacterial activity, toxicity to brine shrimp Artemia salina, antitumor activity against three tumor cell lines (human cervix carcinoma HeLa cells, human melanoma FemX cells, and human myelogenous leukemia K562 cells) and toxicity against peripheral blood mononuclear cells were evaluated. Three tested compounds, namely 11, 13, and 15, showed strong activity against all three cell lines, the IC50 values being in the range of 4-10 μM.",
publisher = "Elsevier Science Inc, New York",
journal = "Steroids",
title = "Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives",
volume = "72",
number = "1",
pages = "31-40",
doi = "10.1016/j.steroids.2006.10.002"
}
Gaši K, Brenesel M, Djurendić E, Sakač M, Čanadi J, Daljev J, Armbruster T, Andrić S, Sladić D, Božić TT, Novaković I, Juranić Z. Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives. Steroids. 2007;72(1):31-40
Gaši, K.M.P., Brenesel, M.Dj.D., Djurendić, E.A., Sakač, M., Čanadi, J.J., Daljev, J.J., Armbruster, T., Andrić, S., Sladić, D., Božić, T. T., Novaković, I.,& Juranić, Z. (2007). Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives.
SteroidsElsevier Science Inc, New York., 72(1), 31-40.
https://doi.org/10.1016/j.steroids.2006.10.002
Gaši K.M.P., Brenesel M.Dj.D., Djurendić E.A., Sakač Marija, Čanadi J.J., Daljev J.J., Armbruster T., Andrić Silvana, Sladić Dušan, Božić Tatjana T., Novaković Irena, Juranić Zorica, "Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives" 72, no. 1 (2007):31-40,
https://doi.org/10.1016/j.steroids.2006.10.002 .

DSpace software copyright © 2002-2015  DuraSpace
О Централном репозиторијуму (ЦеР) | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумИнституцијеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О Централном репозиторијуму (ЦеР) | Пошаљите запажања

OpenAIRERCUB