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dc.creatorPantelić, Nebojša Đ.
dc.creatorZmejkovski, Bojana
dc.creatorBožić, Bojan
dc.creatorDojčinović, Biljana
dc.creatorBanjac, Nebojša R.
dc.creatorWessjohann, Ludger A.
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2020-09-15T13:15:53Z
dc.date.available2022-07-26
dc.date.issued2020
dc.identifier.issn0162-0134
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3654
dc.description.abstractTwo novel triphenyltin(IV) compounds, [Ph3SnL1] (L1 = 2-(5-(4-fluorobenzylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (1)) and [Ph3SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole-3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (1H and 13C) NMR spectroscopy,mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV)compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), andHepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystalviolet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 μM. Compound 1 exhibits thehighest activity toward PC-3 cells (IC50 = 0.115 } 0.009 μM; CV assay). The tin and platinum uptake in PC-3cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higheractivity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometryanalysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175033/RS//sr
dc.relationGerman Academic Exchange Service (DAAD) - grant number: 57448219sr
dc.rightsembargoedAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Inorganic Biochemistrysr
dc.subjectTin(IV)sr
dc.subjectIn vitrosr
dc.subjectProstate cancersr
dc.subjectApoptosissr
dc.subjectAutophagysr
dc.subjectNOsr
dc.titleSynthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4- dioxothiazolidin-3-yl)propanoic aciden
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractКалуђеровић, Горан Н.; Пантелић, Небојша Ђ.; Змејковски, Бојана; Божић, Бојан; Дојчиновић, Биљана; Бањац, Небојша Р.; Wессјоханн, Лудгер A.;
dc.citation.volume212
dc.citation.spage111207
dc.citation.rankM21~
dc.description.otherThis is the peer-reviewed version of the article: Nebojša Đ. Pantelić, Bojana B. Zmejkovski, Bojan Božić, Biljana Dojčinović, Nebojša R. Banjac, Ludger A. Wessjohann, Goran N. Kaluđerović, Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4- dioxothiazolidin-3-yl)propanoic acid, Journal of Inorganic Biochemistry, 2020, 212, 111207, doi: [https://doi.org/10.1016/j.jinorgbio.2020.111207]
dc.description.otherThe published version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3653]
dc.identifier.pmid32801055
dc.identifier.doi10.1016/j.jinorgbio.2020.111207
dc.identifier.scopus2-s2.0-85089264363
dc.identifier.wos000566344500012
dc.type.versionacceptedVersionsr


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