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dc.creatorPantelić, Nebojša Đ.
dc.creatorZmejkovski, Bojana
dc.creatorBožić, Bojan
dc.creatorDojčinović, Biljana
dc.creatorBanjac, Nebojša R.
dc.creatorWessjohann, Ludger A.
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2020-09-15T13:10:25Z
dc.date.available2020-09-15T13:10:25Z
dc.date.issued2020
dc.identifier.issn0162-0134
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/3653
dc.description.abstractTwo novel triphenyltin(IV) compounds, [Ph3SnL1] (L1 = 2-(5-(4-fluorobenzylidene)-2,4-dioxotetrahydrothiazole- 3-yl)propanoate (1)) and [Ph3SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole- 3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (1H and 13C) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 μM. Compound 1 exhibits the highest activity toward PC-3 cells (IC50 = 0.115 } 0.009 μM; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175033/RS//sr
dc.relationGerman Academic Exchange Service (DAAD) - grant number: 57448219sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Inorganic Biochemistrysr
dc.subjectTin(IV)sr
dc.subjectIn vitrosr
dc.subjectProstate cancersr
dc.subjectApoptosissr
dc.subjectAutophagysr
dc.subjectNOsr
dc.titleSynthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4- dioxothiazolidin-3-yl)propanoic aciden
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractЗмејковски, Бојана; Пантелић, Небојша Ђ.; Wессјоханн, Лудгер A.; Калуђеровић, Горан Н.; Божић, Бојан; Бањац, Небојша Р.; Дојчиновић, Биљана;
dc.citation.volume212
dc.citation.spage111207
dc.citation.rankM21~
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3654]
dc.identifier.pmid32801055
dc.identifier.doi10.1016/j.jinorgbio.2020.111207
dc.identifier.scopus2-s2.0-85089264363
dc.identifier.wos000566344500012
dc.type.versionpublishedVersionsr


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