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Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4- dioxothiazolidin-3-yl)propanoic acid
dc.creator | Pantelić, Nebojša Đ. | |
dc.creator | Zmejkovski, Bojana | |
dc.creator | Božić, Bojan | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Banjac, Nebojša R. | |
dc.creator | Wessjohann, Ludger A. | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2020-09-15T13:10:25Z | |
dc.date.available | 2020-09-15T13:10:25Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3653 | |
dc.description.abstract | Two novel triphenyltin(IV) compounds, [Ph3SnL1] (L1 = 2-(5-(4-fluorobenzylidene)-2,4-dioxotetrahydrothiazole- 3-yl)propanoate (1)) and [Ph3SnL2] (L2 = 2-(5-(5-methyl-2-furfurylidene)-2,4-dioxotetrahydrothiazole- 3-yl)propanoate (2)) were synthesized and characterized by FT-IR, (1H and 13C) NMR spectroscopy, mass spectrometry, and elemental microanalysis. The in vitro anticancer activity of the synthesized organotin(IV) compounds was determined against four tumor cell lines: PC-3 (prostate), HT-29 (colon), MCF-7 (breast), and HepG2 (hepatic) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. The IC50 values are found to be in the range from 0.11 to 0.50 μM. Compound 1 exhibits the highest activity toward PC-3 cells (IC50 = 0.115 } 0.009 μM; CV assay). The tin and platinum uptake in PC-3 cells showed a threefold lower uptake of tin in comparison to platinum (as cisplatin). Together with its higher activity this indicates a much higher cell inhibition potential of the tin compounds (calculated to ca. 50 to 100 times). Morphological analysis suggested that the compounds induce apoptosis in PC-3 cells, and flow cytometry analysis revealed that 1 and 2 induce autophagy as well as NO (nitric oxide) production. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175033/RS// | sr |
dc.relation | German Academic Exchange Service (DAAD) - grant number: 57448219 | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Inorganic Biochemistry | sr |
dc.subject | Tin(IV) | sr |
dc.subject | In vitro | sr |
dc.subject | Prostate cancer | sr |
dc.subject | Apoptosis | sr |
dc.subject | Autophagy | sr |
dc.subject | NO | sr |
dc.title | Synthesis, characterization and in vitro biological evaluation of novel organotin(IV) compounds with derivatives of 2-(5-arylidene-2,4- dioxothiazolidin-3-yl)propanoic acid | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Змејковски, Бојана; Пантелић, Небојша Ђ.; Wессјоханн, Лудгер A.; Калуђеровић, Горан Н.; Божић, Бојан; Бањац, Небојша Р.; Дојчиновић, Биљана; | |
dc.citation.volume | 212 | |
dc.citation.spage | 111207 | |
dc.citation.rank | M21~ | |
dc.description.other | The peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3654] | |
dc.identifier.pmid | 32801055 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2020.111207 | |
dc.identifier.scopus | 2-s2.0-85089264363 | |
dc.identifier.wos | 000566344500012 | |
dc.type.version | publishedVersion | sr |