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dc.creatorKrstić, Natalija
dc.creatorBjelaković, Mira
dc.creatorŽižak, Željko
dc.creatorPavlović, M.D.
dc.creatorJuranić, Zorica
dc.creatorPavlović, Vladimir D.
dc.date.accessioned2019-01-30T17:16:38Z
dc.date.available2019-01-30T17:16:38Z
dc.date.issued2007
dc.identifier.issn0039-128X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/363
dc.description.abstractThe antiproliferative activity of previously synthesized (Z)-cholest-4-en-6-one oxime (1), (E)-cholest-4-en-6-one oxime (2), 7-aza-B-homocholest-4-en-6-one (3) and 6-aza-B-homocholest-4-en-7-one (4) and newly synthesized 6-thioxo-7-aza-B-homocholest-4-ene (5) and 6-aza-7-thioxo-B-homocholest-4-ene (6) was tested for their possible effects against two human tumor cell lines, cervical carcinoma (HeLa) and chronic myelogenous leukemia (K-562). Compounds 1-6, exerted a dose-dependent antiproliferative effect toward cell lines used in experimental design, showing high selectivity in their action for tumor cells in comparison to normal immunocompetent cells (non-stimulated PBMC and PHA-stimulated PBMC). Compounds 2, 3 and 4 exhibited a very high but selective antitumor activity, by inducing apoptosis in sensitive, for that purpose targeted tumor cell line (HeLa cells). Low toxic effect upon both non-stimulated, and PHA stimulated PBMCs from control, healthy volunteers, has been detected for compounds 1, 2, 3 and 4. The possible reasons for profound differences in the effects of this spectrum of steroidal compounds between tumor cell lines and normal stimulated and non-stimulated PBMCs are discussed. The molecular mechanisms for apoptotic events in HeLa cell line are suggested. The guidelines for further research are underlined.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142033/RS//
dc.rightsrestrictedAccess
dc.sourceSteroids
dc.subjectAntiproliferative activityen
dc.subjectSteroidal lactamsen
dc.subjectSteroidal oximesen
dc.subjectSteroidal thiolactamsen
dc.titleSynthesis of some steroidal oximes, lactams, thiolactams and their antitumor activitiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПавловић, Владимир Д.; Крстић, Наталија; Павловић, М.Д.; Јуранић, З.Д.; Жижак, З.; Бјелаковић, Мира;
dc.citation.volume72
dc.citation.issue5
dc.citation.spage406
dc.citation.epage414
dc.citation.other72(5): 406-414
dc.citation.rankM22
dc.identifier.pmid17433824
dc.identifier.doi10.1016/j.steroids.2007.02.005
dc.identifier.rcubConv_4066
dc.identifier.scopus2-s2.0-34247205206
dc.identifier.wos000246604100002
dc.type.versionpublishedVersion


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