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dc.creatorKonstantinović, Jelena M.
dc.creatorVidenović, Milica
dc.creatorOrsini, Stefania
dc.creatorBogojević, Katarina
dc.creatorD'Alessandro, Sarah
dc.creatorScaccabarozzi, Diletta
dc.creatorTerzić-Jovanović, Nataša
dc.creatorGradoni, Luigi
dc.creatorBasilico, Nicoletta
dc.creatorŠolaja, Bogdan
dc.date.accessioned2020-08-19T21:09:22Z
dc.date.available2019-05-06
dc.date.issued2018
dc.identifier.issn1948-5875
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3626
dc.description.abstractIn this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten compounds demonstrated IC50 LT 1 mu M against promastigote stages of L. infantum and L. tropica, and five compounds showed IC50 LT 1 mu M against intramacrophage L. infantum amastigotes. Two compounds showed dose-dependent enhancement of NO and ROS production by bone marrow-derived macrophages and remarkable reduction of parasite load in vivo, with advantage of being short-term and orally active. To the best of our knowledge, this is the first example of 4-amino-7-chloroquinoline derivatives active in Leishmania infantum infected mice.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//
dc.relationMinistero dellIstruzione, dellUniversita e della Ricerca (PRIN) Project [20154JRJPP_004]
dc.relationSerbian Academy of Sciences and Arts, Executive Programme of Scientific and Technological Cooperation between the Italian Republic and the Republic of Serbia
dc.rightsembargoedAccess
dc.sourceAcs Medicinal Chemistry Letters
dc.subjectLeishmania infantumen
dc.subjectpromastigoteen
dc.subjectamastigoteen
dc.subjectmice modelen
dc.subjectaminoquinolineen
dc.titleNovel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Miceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГрадони, Луиги; Константиновиц, Јелена; Виденовић, Милица; Шолаја, Богдан; Басилицо, Ницолетта; Орсини, Стефаниа; Богојевић, Катарина; Д'Aлессандро, Сарах; Сцаццабароззи, Дилетта; Терзић Јовановић, Наташа;
dc.citation.volume9
dc.citation.issue7
dc.citation.spage629
dc.citation.epage634
dc.citation.other9(7): 629-634
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the following article: Konstantinović, J.; Videnović, M.; Orsini, S.; Bogojević, K.; D’Alessandro, S.; Scaccabarozzi, D.; Terzić Jovanović, N.; Gradoni, L.; Basilico, N.; Šolaja, B. A. Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania Infantum Infected Mice. ACS Medicinal Chemistry Letters 2018, 9 (7), 629–634. [https://doi.org/10.1021/acsmedchemlett.8b00053]
dc.description.otherThe published version: [http://cer.ihtm.bg.ac.rs/handle/123456789/2428]
dc.identifier.pmid30034591
dc.identifier.doi10.1021/acsmedchemlett.8b00053
dc.identifier.rcubConv_3984
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/17186/ACC_2018_acsmedchemlett.8b00053.pdf
dc.identifier.scopus2-s2.0-85046787760
dc.identifier.wos000442964000011
dc.type.versionacceptedVersion


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