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dc.creatorVajdle, Olga
dc.creatorŠekuljica, Sanja
dc.creatorGuzsvány, Valéria
dc.creatorNagy, László
dc.creatorKónya, Zoltán
dc.creatorAvramov Ivić, Milka
dc.creatorMijin, Dušan
dc.creatorPetrović, Slobodan D.
dc.creatorAnojčić, Jasmina
dc.date.accessioned2020-08-19T06:38:26Z
dc.date.available2020-08-19T06:38:26Z
dc.date.issued2020
dc.identifier.issn1572-6657
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3615
dc.description.abstractIn this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200125/RS//sr
dc.relationCEEPUSIII (CZ-0212-13- 1920)sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Electroanalytical Chemistrysr
dc.subjectMacrolide antibioticssr
dc.subjectSquare wave voltammetrysr
dc.subjectCarbon paste electrodesr
dc.subjectGold nanoparticlessr
dc.subjectPharmaceutical preparationssr
dc.titleUse of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparationssr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractAврамов Ивић, Милка; Мијин, Душан; Вајдле, Олга; Шекуљица, Сања; Гузсвáнy, Валéриа; Aнојчић, Јасмина; Петровић, Слободан; Нагy, Лáсзлó; Кóнyа, Золтáн;
dc.rights.holderElseviersr
dc.citation.volume873
dc.citation.spage114324
dc.citation.rankM21~
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3619]
dc.identifier.doi10.1016/j.jelechem.2020.114324
dc.identifier.scopus2-s2.0-85086820704
dc.type.versionpublishedVersionsr


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