Приказ основних података о документу
Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines
dc.creator | Wittine, Karlo | |
dc.creator | Antolović, Roberto | |
dc.creator | Jelić, Dubravko | |
dc.creator | Bracanović, Sara | |
dc.creator | Cetina, Mario | |
dc.creator | Anđelković, Uroš | |
dc.creator | Wittine, Ozren | |
dc.creator | Kraljević Pavelić, Sandra | |
dc.creator | Vinter, Adrijana | |
dc.date.accessioned | 2020-08-18T11:21:36Z | |
dc.date.available | 2020-08-18T11:21:36Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3614 | |
dc.description.abstract | Furanocoumarins, particularly furo[3,2-c]coumarins, are found in many natural products. However, coumarins annulated to a thiophene ring have received scarce attention to date in the literature. Therefore, we synthesized 4-oxo-4H-thieno[3,2-c]chromene derivatives and tested in vitro their anti-inflammatory activity. Anti-inflammatory potential of the synthesized compounds (1, 2, 6–8, 9a–e and 10a–c) has been evaluated by measuring various pSTAT (signal transducer and activator of transcription) inhibition within the JAK (Janus-activated family kinase)/STAT signaling pathway. Ethyl 7-hydroxy-4-oxo-4H-thieno[3,2-c]chromene-2-carboxylate (7) showed best inhibition properties on pSTAT5 in GM-CSF (Granulocyte-macrophage colony-stimulating factor)-triggered PBMC assay, with IC50 value of 5.0 μM. | en |
dc.language.iso | en | sr |
dc.publisher | Elsevier | sr |
dc.relation | University of Rijeka research grant 13.11.1.1.11 (RISK “Development of University of Rijeka campus laboratory research infrastructure”) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Bioorganic & Medicinal Chemistry Letters | sr |
dc.subject | Thieno[3,2-c]chromene | sr |
dc.subject | Coumarin | sr |
dc.subject | Anti-inflammatory | sr |
dc.subject | Interleukin | sr |
dc.subject | Cytokine | sr |
dc.title | Thienochromene derivatives inhibit pSTAT1 and pSTAT5 signaling induced by cytokines | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Wиттине, Озрен; Краљевић Павелић, Сандра; Винтер, Aдријана; Wиттине, Карло; Aнтоловић, Роберто; Јелић, Дубравко; Брацановић, Сара; Aнђелковић, Урош; Цетина, Марио; | |
dc.rights.holder | Elsevier | sr |
dc.citation.volume | 30 | |
dc.citation.issue | 18 | |
dc.citation.spage | 127415 | |
dc.citation.rank | M22~ | |
dc.identifier.pmid | 32717616 | |
dc.identifier.doi | 10.1016/j.bmcl.2020.127415 | |
dc.identifier.scopus | 2-s2.0-85088107865 | |
dc.identifier.wos | 000571824300011 | |
dc.type.version | publishedVersion | sr |