Role of aromatic amino acids in amyloid self-assembly
2020
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Amyloids are proteins of a cross-β structure found as deposits in several diseases and also in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in amyloid deposits. Although they are not indispensable, aromatic amino acids, phenylalanine, tyrosine and tryptophan, enhance significantly the kinetics of formation and thermodynamic stability, while tape or ribbon-like morphology is represented in systems with experimentally detected π-π interactions between aromatic rings. Analysis of geometries and energies of the amyloid PDB structures indicate the prevalence of aromatic-nonaromatic interactions and confirm that aromatic-aromatic interactions are not crucial for the amyloid formation.
Кључне речи:
Amyloids / Aromatic amino acids / Self-assemblyИзвор:
International Journal of Biological Macromolecules, 2020, 156, 949-959Издавач:
- Elsevier
Финансирање / пројекти:
- Нековалентне интеракције pi-система и њихова улога у молекулском препознавању (RS-MESTD-Basic Research (BR or ON)-172065)
- NPRP grant from the Qatar National Research Fund (a member of the Qatar Foundation) [grant number NPRP8-425-1-087].
- NSF (CHE-1664866)
Напомена:
- This is the peer-reviewed version of the article: Ivana M. Stanković, Shuqiang Niu, Michael B. Hall, Snežana D. Zarić, Role of aromatic amino acids in amyloid self-assembly, International Journal of Biological Macromolecules, 2020, 156, 949-959, https://doi.org/10.1016/j.ijbiomac.2020.03.064
- Published version: http://cer.ihtm.bg.ac.rs/handle/123456789/3606
DOI: 10.1016/j.ijbiomac.2020.03.064
ISSN: 0141-8130
PubMed: 32199918
WoS: 000538104200097
Scopus: 2-s2.0-85085469915
Институција/група
IHTMTY - JOUR AU - Stanković, Ivana AU - Niu, Shuqiang AU - Hall, Michael B. AU - Zarić, Snežana D. PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3609 AB - Amyloids are proteins of a cross-β structure found as deposits in several diseases and also in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in amyloid deposits. Although they are not indispensable, aromatic amino acids, phenylalanine, tyrosine and tryptophan, enhance significantly the kinetics of formation and thermodynamic stability, while tape or ribbon-like morphology is represented in systems with experimentally detected π-π interactions between aromatic rings. Analysis of geometries and energies of the amyloid PDB structures indicate the prevalence of aromatic-nonaromatic interactions and confirm that aromatic-aromatic interactions are not crucial for the amyloid formation. PB - Elsevier T2 - International Journal of Biological Macromolecules T1 - Role of aromatic amino acids in amyloid self-assembly VL - 156 SP - 949 EP - 959 DO - 10.1016/j.ijbiomac.2020.03.064 ER -
@article{ author = "Stanković, Ivana and Niu, Shuqiang and Hall, Michael B. and Zarić, Snežana D.", year = "2020", abstract = "Amyloids are proteins of a cross-β structure found as deposits in several diseases and also in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in amyloid deposits. Although they are not indispensable, aromatic amino acids, phenylalanine, tyrosine and tryptophan, enhance significantly the kinetics of formation and thermodynamic stability, while tape or ribbon-like morphology is represented in systems with experimentally detected π-π interactions between aromatic rings. Analysis of geometries and energies of the amyloid PDB structures indicate the prevalence of aromatic-nonaromatic interactions and confirm that aromatic-aromatic interactions are not crucial for the amyloid formation.", publisher = "Elsevier", journal = "International Journal of Biological Macromolecules", title = "Role of aromatic amino acids in amyloid self-assembly", volume = "156", pages = "949-959", doi = "10.1016/j.ijbiomac.2020.03.064" }
Stanković, I., Niu, S., Hall, M. B.,& Zarić, S. D.. (2020). Role of aromatic amino acids in amyloid self-assembly. in International Journal of Biological Macromolecules Elsevier., 156, 949-959. https://doi.org/10.1016/j.ijbiomac.2020.03.064
Stanković I, Niu S, Hall MB, Zarić SD. Role of aromatic amino acids in amyloid self-assembly. in International Journal of Biological Macromolecules. 2020;156:949-959. doi:10.1016/j.ijbiomac.2020.03.064 .
Stanković, Ivana, Niu, Shuqiang, Hall, Michael B., Zarić, Snežana D., "Role of aromatic amino acids in amyloid self-assembly" in International Journal of Biological Macromolecules, 156 (2020):949-959, https://doi.org/10.1016/j.ijbiomac.2020.03.064 . .