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dc.creatorMarković, Maja
dc.creatorPanić, Vesna
dc.creatorŠešlija, Sanja
dc.creatorMilivojević, Ana D.
dc.creatorSpasojević, Pavle
dc.creatorBošković-Vragolović, Nevenka
dc.creatorPjanović, Rada
dc.date.accessioned2020-08-06T11:36:14Z
dc.date.available2020-08-06T11:36:14Z
dc.date.issued2020
dc.identifier.issn0032-3888
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3604
dc.description.abstractCarriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS— caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.en
dc.language.isoensr
dc.publisherWileysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//sr
dc.rightsrestrictedAccesssr
dc.sourcePolymer Engineering & Sciencesr
dc.subjectliposomessr
dc.subjectnicotinamidesr
dc.subjectpH-sensitive hydrogelssr
dc.subjectpoorly water-soluble substancesr
dc.subjecttargeted deliverysr
dc.titleNovel strategy for encapsulation and targeted delivery of poorly water-soluble active substancesen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractМиливојевић, Aна Д.; Пјановић, Рада В.; Марковић, Маја; Панић, Весна; Шешлија, Сања; Спасојевић, Павле; Бошковић-Враголовић, Невенка;
dc.citation.volume60
dc.citation.spage2008
dc.citation.epage2022
dc.citation.rankM22~
dc.identifier.doi10.1002/pen.25448
dc.identifier.scopus2-s2.0-85086154200
dc.identifier.wos000539099700001
dc.type.versionpublishedVersionsr


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