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Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances

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2020
Authors
Marković, Maja
Panić, Vesna
Šešlija, Sanja
Milivojević, Ana D.
Spasojević, Pavle
Bošković-Vragolović, Nevenka
Pjanović, Rada
Article (Published version)
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Abstract
Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS— caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated dep...ending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.

Keywords:
liposomes / nicotinamide / pH-sensitive hydrogels / poorly water-soluble substance / targeted delivery
Source:
Polymer Engineering & Science, 2020
Publisher:
  • Wiley
Projects:
  • Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
  • Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)

DOI: 10.1002/pen.25448

ISSN: 0032-3888

WoS: 000539099700001

Scopus: 2-s2.0-85086154200
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3604
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IHTM

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