Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances
Authorized Users Only
2020
Authors
Marković, Maja
Panić, Vesna

Šešlija, Sanja

Milivojević, Ana D.
Spasojević, Pavle

Bošković-Vragolović, Nevenka
Pjanović, Rada

Article (Published version)

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Show full item recordAbstract
Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated dep...ending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.
Keywords:
liposomes / nicotinamide / pH-sensitive hydrogels / poorly water-soluble substance / targeted deliverySource:
Polymer Engineering & Science, 2020Publisher:
- Wiley
Projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-172026)
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)
DOI: 10.1002/pen.25448
ISSN: 0032-3888