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dc.creatorTsoukatou, M.
dc.creatorMaréchal, J.P.
dc.creatorHellio, C.
dc.creatorNovaković, Irena
dc.creatorTufegdžić, Srđan
dc.creatorSladić, Dušan
dc.creatorGašić, Miroslav J.
dc.creatorClare, A.S.
dc.creatorVagias, C.
dc.creatorRoussis, V.
dc.date.accessioned2019-01-30T17:16:32Z
dc.date.available2019-01-30T17:16:32Z
dc.date.issued2007
dc.identifier.issn1420-3049
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/359
dc.description.abstractThe sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3′-(p-chlorophenyl) avarone (3), 3′,4′-ethylenedithioavarone (4), 4′-isopropylthioavarone (5), 4′-tert-butylthioavarone (6), 4′-propylthioavarone (7), 4′-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 μg/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).en
dc.publisherMDPI AG
dc.rightsopenAccess
dc.sourceMolecules
dc.subjectAntifouling activityen
dc.subjectAntimicrobial activityen
dc.subjectAvarolen
dc.subjectAvaroneen
dc.subjectSettlement inhibitionen
dc.titleEvaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganismsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractРоуссис, В.; Вагиас, Ц.; Цларе, A.С.; Гашић, М.Ј.; Сладић, Д.; Хеллио, Ц.; Марéцхал, Ј.П.; Тсоукатоу, М.; Новаковић, Ирена; Туфегджић, Срђан;
dc.citation.volume12
dc.citation.issue5
dc.citation.spage1022
dc.citation.epage1034
dc.citation.other12(5): 1022-1034
dc.citation.rankM23
dc.identifier.pmid17873837
dc.identifier.doi10.3390/12051022
dc.identifier.rcubConv_4070
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/9022/357.pdf
dc.identifier.scopus2-s2.0-34249870148
dc.identifier.wos000247200900009
dc.type.versionpublishedVersion


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