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dc.creatorTomić, Mirko
dc.creatorIgnjatović, D.
dc.creatorTovilović, Gordana
dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:16:27Z
dc.date.available2019-01-30T17:16:27Z
dc.date.issued2007
dc.identifier.issn0960-894X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/354
dc.description.abstractTwo new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectArylpiperazinesen
dc.subjectAtypical antipsychoticsen
dc.subjectDopamine receptorsen
dc.subjectSerotonin receptorsen
dc.titleTwo new phenylpiperazines with atypical antipsychotic potentialen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКостић Рајачић, Слађана; Aндрић, Д.; Томић, М.; Товиловић, Г.; Роглић, Г.; Игњатовић, Д.;
dc.citation.volume17
dc.citation.issue21
dc.citation.spage5749
dc.citation.epage5753
dc.citation.other17(21): 5749-5753
dc.citation.rankM22
dc.identifier.pmid17870534
dc.identifier.doi10.1016/j.bmcl.2007.08.066
dc.identifier.rcubConv_4078
dc.identifier.scopus2-s2.0-34648847078
dc.identifier.wos000250287800003
dc.type.versionpublishedVersion


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