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dc.creatorSavić, Danijela
dc.creatorOpačić, Miloš
dc.creatorRistić, Aleksandar J.
dc.creatorSokić, Dragoslav
dc.creatorBaščarević, Vladimir
dc.creatorRaičević, Savo
dc.creatorSavić, Slobodan
dc.creatorŽivin, Marko
dc.creatorŠelih, Vid Simon
dc.creatorSpasić, Snežana
dc.creatorSpasojević, Ivan
dc.date.accessioned2020-05-14T12:48:27Z
dc.date.available2020-05-14T12:48:27Z
dc.date.issued2018
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3543
dc.description.abstractThe accumulating evidence on the relation between the disturbed metal homeostasis and epilepsy urges the need for data regarding the total metal concentrations, as well as metal distribution in the brain itself, in order to indicate where to direct the potential therapy, to metal supplementation or chelation. This paper summarizes our results on the measurements of some important essential metals in hippocampi of patients with mesial temporal lobe epilepsy (mTLE) who underwent amigdalohippocampectomy. The key findings point out that levels of copper and manganese are deficient in hippocampi of mTLE patients, and that their concentrations correlated positively with neuronal loss in affected regions of sclerotic hippocampus. In addition, the Cu concentration was decreased in the areas of total neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor deficient compared to control. Our results contribute to deeper insight of metals biology in the epilepsy and may represent the initial point of new and non-invasive therapy of drug resistant epilepsy.sr
dc.language.isoensr
dc.publisherSerbian Biochemical Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//sr
dc.relationSlovenian Research Agency (ARRS), Project numbers P3-0171 and P1-0034sr
dc.rightsopenAccesssr
dc.sourceSerbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbiasr
dc.titleDistribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsysr
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractСпасојевић, Иван; Спасић, Снежана; Шелих, Вид Симон; Живин, Марко; Савић, Данијела; Савић, Слободан; Опачић, Милош; Ристић, Aлександар Ј.; Сокић, Драгослав; Раичевић, Саво; Башчаревић, Владимир;
dc.citation.spage105
dc.citation.epage112
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/16504/bitstream_16504.pdf
dc.type.versionpublishedVersionsr


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