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Distribution and role of metals in sclerotic hippocampi of patients with mesial temporal lobe epilepsy

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Authors
Savić, Danijela
Opačić, Miloš
Ristić, Aleksandar J.
Sokić, Dragoslav
Baščarević, Vladimir
Raičević, Savo
Savić, Slobodan
Živin, Marko
Šelih, Vid Simon
Spasić, Snežana
Spasojević, Ivan
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Abstract
The accumulating evidence on the relation between the disturbed metal homeostasis and epilepsy urges the need for data regarding the total metal concentrations, as well as metal distribution in the brain itself, in order to indicate where to direct the potential therapy, to metal supplementation or chelation. This paper summarizes our results on the measurements of some important essential metals in hippocampi of patients with mesial temporal lobe epilepsy (mTLE) who underwent amigdalohippocampectomy. The key findings point out that levels of copper and manganese are deficient in hippocampi of mTLE patients, and that their concentrations correlated positively with neuronal loss in affected regions of sclerotic hippocampus. In addition, the Cu concentration was decreased in the areas of total neuronal loss. Iron and zinc total hippocampal levels were neither accumulated nor deficient compared to control. Our results contribute to deeper insight of metals biology in the epilepsy and may... represent the initial point of new and non-invasive therapy of drug resistant epilepsy.

Source:
Serbian Biochemical Society Eighth Conference with international participation, “Coordination in Biochemistry and Life”, University of Novi Sad – Rectorate Hall, 16.11.2018. Novi Sad, Serbia, 2018, 105-112
Publisher:
  • Serbian Biochemical Society
Projects:
  • Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-41014)
  • Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)
  • Slovenian Research Agency (ARRS), Project numbers P3-0171 and P1-0034
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3543
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IHTM

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